With the high incidence of toxic chemicals in our environment, food, water, medications and even body tissues, some individuals experience an accumulation of harmful compounds in their bodies. A concentration of such substances can lead to a variety of metabolic dysfunctions, particularly to the immune, neurological and endocrine systems of the body. Additionally, fat build up in the liver can lead to liver damage. Patient One LiverCare™ is a synergistic blend of antioxidants, vitamins, herbs and amino acids that enhance the body’s ability to detoxify and protect the liver. This unique combination aids in fat metabolism within the liver, promotes glutathione synthesis, supports the safe elimination of toxins and supplies antioxidants to help reduce free radical damage.
Prior to embarking on a detoxification program it is important to achieve optimal bowel function. Therefore, we recommend using a fiber formula such as Patient One C-Cleanse as it supports the elimination of toxins from the body, binding toxins released into the intestines from the liver and preventing their reabsorption.
Milk Thistle Extract:
A common herb native to the Mediterranean, milk thistle has been broadly used for its nutritional support of liver function for two centuries. Seeds of the dried milk thistle flower are rich in silymarin, a bioflavonoid complex of silybin, silydianin, and silychristin. Silymarin protects the liver from free radical damage, supports glutathione concentrations and promotes superoxide dismutase activity. Milk thistle extract also stimulates protein synthesis in hepatic cells.
Vitamin C aids the detox process by limiting damage to the body from free radicals. Vitamin C strengthens the immune system and is especially effective in helping the body rid itself of heavy metal toxins like mercury, lead, cadmium and nickel.
Selenium is a trace mineral with an important role in detoxification. It is a cofactor for the production of glutathione peroxidase, a form of glutathione that enhances antioxidant protection against free radical damage. Selenium assists in the detox of heavy metals by enhancing the activity of lymphocytes and macrophages.
Glutathione (GSH) plays critical roles in protecting cells from oxidative damage and maintaining redox homeostasis. GSH is the most important low molecular weight antioxidant synthesized in cells. As a reducing molecule it reacts with oxygen species by neutralizing the unpaired electrons that make them highly reactive and dangerous. Over- production of reactive oxygen species impairs the intracellular GSH homeostasis, leading to GSH deficiency, a pathophysiological marker in alcoholic and non-alcoholic liver diseases. Evidence from experimental research and previous clinical studies shows glutathione administration appears a promising strategy to recover oxidative stress-induced liver damages in alcoholic and non-alcoholic liver diseases.
Alpha Lipoic Acid:
Insulin resistance, oxidative stress, inflammation and innate immune system activation contribute to the development of non-alcoholic fatty liver disease (NAFLD) through steatosis and inflammation in the liver. The antioxidant α-lipoic acid (ALA) has been shown to improve insulin sensitivity and suppress inflammatory responses. ALA has been shown to improve liver antioxidative capacity by increasing total superoxide dismutase (tSOD), manganese SOD (MnSOD), and copper/zinc-SOD (Cu/ZnSOD) activity as well as glutathione (GSH) content.
Dandelion root has been studied for its protective effects on the liver, specifically protecting the body against cellular damage and abnormal growths caused by toxic chemicals. Used in traditional Chinese medicine for a variety of health benefits, Dandelion contains protective flavonoids that have been shown to have a capacity to scavenge free radicals, sequester metal ions, and reduce the breakage of supercoiled DNA strands induced by hydroxyl free radicals.
Artichoke extract aids the digestive process by promoting healthy bile flow and intestinal motility, reducing toxin exposure in the gut. It also supports hepatic cell function and blood flow in the liver. Studies have shown antioxidative and protective properties against oxidative stress in animal hepatocytes. Also, it has shown to provide protection of lipoprotein from oxidation and inhibition of hemolysis in vitro.
Turmeric Extract & Bioperine®:
Studies of plant phytochemicals and their potential beneficial effects on liver and digestive tract functionality has shown, artichoke, dandelion, and particularly turmeric have notable antioxidant activity. The strong antioxidant activity exhibited by turmeric extract is largely confirmed by studies and suggests that intake, even at low dosage can provide a significant protection against oxidative damage. LiverCare includes Bioperine®, a patented extract derived from the common black pepper fruit that contains the alkaloid piperine. Black pepper has been shown to enhance the bioavailability and promote absorption of curcumin both in pre-clinical studies and in studies on human volunteers.
BroccoSinolate® Broccoli Extract:
Broccoli sprouts are a rich source of glucosinolates and isothiocyanates that induce phase 2 detoxication enzyme, and boost antioxidant status. Glucosinolates are hydrolyzed by myrosinase (an enzyme found in plants and bowel microflora) to form isothiocyanates. BroccoSinolate® ingredients were developed to capitalize on the health benefits of glucosinolates.