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Alpha Lipoic Acid 600 mg

Alpha Lipoic Acid 600 mg
gluten free vegetarian vegetable capsule Non GMO Supplement

Provides whole-body, multi-functional antioxidant activity to support healthy, well-functioning cells

  • Coenzyme for glucose uptake and utilization
  • Promotes healthy vascular and endothelial function
  • Supports regeneration of vitamins C and E
  • Promotes healthy intracellular glutathione levels
  • Supports liver detoxification

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Product Information Sheet (PDF)

Alpha Lipoic Acid (ALA) is a fat- and water-soluble nutrient with antioxidant activity. A sulfur-containing compound present in human cells, it is required for energy production within the mitochondria and provides protection both inside and outside the cell. ALA has the ability to regenerate and extend the biochemical lifetime of other antioxidants, such as vitamins C and E, as well as glutathione and coenzyme Q10 (CoQ10). As such, it plays a role in fighting oxidative stress and free radical formation. As a coenzyme, ALA is needed to break down glucose for energy metabolism. 

This versatile nutrient has been shown to support vascular and connective tissue health, protect cell structures, support the nervous system, help maintain healthy liver function and maintain cholesterol and blood glucose levels within normal ranges. Because of its antioxidant properties and its ability to improve blood vessel circulation to the nerves, ALA has been studied for its ability to improve circulation, particularly in the nervous system.

Alpha lipoic acid can be made in the body but production declines with age. ALA supports healthy aging, helping to neutralize free radicals before they can cause damage to the elastin and collagen in the skin that can be linked to signs of aging and wrinkles. ALA also provides support for althletes by producing energy in muscles and directing calories into energy production. 

Research

  • More than a dozen clinical trials have studied the role of alpha lipoid acid in maintaining healthy nerve function. Findings demonstrate its neuroprotective function, believed to be due to ALA's ability to modulate nitric oxide metabolite activity and to promote healthy microcirculation.

References

  1. Evans JL, Goldfine ID: Lipoic acid: a multi-functional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Therap 2:401-413, 2000
  2. Li Y, Liu YZ, Shi JM, et al. Alpha lipoic acid protects lens from H(2)O(2)-induced cataract by inhibiting apoptosis of lens epithelial cells and inducing activation of anti-oxidative enzymes. Asian Pac J Trop Med. 2013 Jul;6(7):548-51. [PMID: 23768827]
  3. Pershadsingh HA. Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome. Expert Opin Investig Drugs. 2007 Mar;16(3):291-302 [PMID: 17302524]
  4. Foster TS. Efficacy and safety of {alpha}-lipoic acid supplementation in the treatment of symptomatic diabetic neuropathy. Diabetes Educ. 2007 Jan- Feb;33(1):111-7 [PMID: 17272797]
  5. Singh VP, Bali A, Singh N, et al. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol. 2014 Feb;18(1):1-14. Epub 2014 Feb 13. [PMID: 24634591]
  6. Teichert J, Kern J, Tritschler HJ, Ulrich H, Preiss R: Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. Int.J.Clin. Pharmacol.Ther. 36:625-628, 1998
  7. Winkler BS, Boulton ME, Gottsch JD, et al. Oxidative damage and age-related macular degeneration. Mol Vis. 1999 Nov 3;5:32. [PMID: 10562656]
  8. Xiang GD, Sun HL, Zhao LS, Hou J, Yue L, Xu L. The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycemia during OGTT in impaired glucose tolerance. Clin Endocrinol (Oxf) (2008)68(5):716-23.
  9. Packer L, Cadenas E. Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. J Clin Biochem Nutr (2011) 48(1):26-32.
  10. Wang Y, Li X, Guo Y, Chan L, Guan X. Alpha-Lipoc acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor gamma coactivator-1alpha signaling in the skeletal muscle of aged mice. Metabolism (2010)59(7):967-76.
  11. Saliminen A, Jyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-kB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl)(2011) 89(7):667-76.
  12. Lee, Jung Eun, and Chin-ok Yi, et al. "Alpha-lipoc Acid Attenuates Cardiac Fibrosis in Otsuka Long-Evans Toskushima Fatty Rats." Cardio Vascular Diabetology. Cardio Vascular Diabetology, n.d.
  13. Chun, Jun Li, Lv Lin, and Yu De Min. "Cardiac Fibrosis and Dysfunction in Experimental Diabetic Cardiomyopathy Are Ameliorated by Alpha- Lipoid Acid." Cardio Vascular Diabetology. Cardio Vascular Diabetology, n.d.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving % Daily Value**
Alpha Lipoic Acid 600 mg
† Daily Value not established.


Suggested Use

Take 1 capsule twice daily, preferably with meals, or as directed by a qualified health care professional. May take up to 1800 mg daily.

Warnings

If you are pregnant, nursing, or taking any medications, consult your doctor before use. Discontinue use and consult doctor if any adverse reactions occur.

 
Alpha Lipoic Acid 600 mg Label