Niacin 500 mg Flush Free (120 capsules)

Niacin 500 mg Flush Free (120 capsules)
gluten free vegetarian vegetable capsule Non GMO Supplement

Each capsule supplies 500 mg of niacin from 625 mg of inositol hexaniacinate, a stable form that releases slowly to avoid the "niacin flush"

  • Supports cardiovascular wellness
  • Maintains circulatory health
  • Promotes nervous system health

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Product Information Sheet (PDF)

Niacin (Vitamin B3) 

Patient One Flush-Free Niacin supplies 500 mg niacin per capsule from a potent serving of 625 mg inositol hexanicotinate, a compound of nicotinic acid (niacin) with inositol. This compound consists of six molecules of niacin and one molecule of inositol. Taken orally, the niacin releases slowly, thereby minimizing the likelihood of "niacin flush."  Because niacin releases histamine and causes capillary dilation which may cause a flushing of the skin, Patient One Niacin 500 mg is designed to promote patient compliance by minimizing this flushing sensation.

Niacin is a water-soluble B vitamin that is involved in nearly all aspects of energy metabolism. Its coenzymes (NAD and NADP) assist in the metabolic processes surrounding the breakdown and utilization of fats, proteins, and carbohydrates. It is most commonly used to support cardiovascular wellness but has also shown benefits for circulatory wellness, blood health and nervous system health.

Evidence suggests that inositol hexanicotinate may have a beneficial effect on endothelium-dependent vasodilation. Improvements in blood flow are therapeutically important in conditions resulting from peripheral vascular insufficiency, such as Raynaud's and leg cramping.


  2. O’Hara J, Jolly PN, Nicol CG. The therapeutic efficacy of inositol nicotinate (Hexopal) in intermittent claudication: a controlled trial. Br J Clin Pract. 1988; 42:377–383.
  3. Ring EF, Bacon PA. Quantitative thermographic assessment of inositol nicotinate therapy in Raynaud’s phenomena. J Int Med Res. 1977;5:217–222.
  4. Hentzer, E. [Treatment of peripheral arterial insufficiency with inositol nicotinate
  5. (Hexanicit)]. Nord.Med. 9-22-1966;76(38):1090-1093.
  6. Holti G. An experimentally controlled evaluation of the effect of inositol
  7. nicotinate upon the digital blood flow in patients with Raynaud’s phenomenon. J
  8. Int Med Res 1979;7:473-83.
  9. Gurakar A, Hoeg JM, Kostner G, et al. Levels of lipoprotein Lp(a) decline with neomycin and niacin treatment. Atherosclerosis. 1985;57:293–301.
  10. Benjó AM, Maranhão RC, Coimbra SR, et al. Accumulation of chylomicron remnants and impaired vascular reactivity occur in subjects with isolated low HDL cholesterol: effects of niacin treatment. Atherosclerosis. 2006;187:116–122.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 120
Amount Per Serving % Daily Value**
Niacin (from 625 mg inositol hexaniacinate) 500 mg 2500%

(from 625 mg inositol hexaniacinate)

125 mg
† Daily Value not established.
** Daily Values are based on a 2,000 calorie per day diet.

Suggested Use

Take 1 vegetable capsule 2 or more times daily in divided doses with meals as a dietary supplement, or as directed by a qualified health care professional.


If you are pregnant, nursing, or taking any medications, consult your doctor before use. Niacin has been reported to cause liver inflammation in some individuals, when taken at a daily dose of more than 500 mg. It is recommended to monitor liver enzymes in individuals taking this product. Niacin in combination with cholesterol medications may adversely affect muscles. It may counter the effects of some diabetes medications. Consult your physician for more information. Discontinue use and consult doctor if any adverse reactions occur.

Niacin 500 mg Flush Free (120 capsules) Label