B-100 Complex

B-100 Complex
gluten free vegetarian

Balanced spectrum of B Vitamins for cellular energy production, nervous system function and cardiovascular health

  • Supports cellular respiration and energy production
  • Promotes healthy triglyceride and lipoprotein levels
  • Enhances MAO activity
  • Supports mental clarity, memory, and focus
  • Optimizes new cell growth
  • Supports glucose metabolism

Discontinued Product

See B-Complex with Quatrefolic® »

Unique Properties

Patient One B-100 Complex supplies 100 mg of each of the B vitamins in a sustained release delivery system. Our balanced B formula supplies folate as pre-converted 5-MTHF, a preferred form for the large portion of the population with a genetic enzyme defect that makes it difficult to convert folic acid into 5-MTHF.  

Particularly supportive of proper nervous system function, Patient One’s B-100 formula provides support for stress, helps maintain normal homocysteine levels, supports brain function and provides wide-ranging health benefits. 

Key Ingredients

Thiamine (as Thiamine HCl) B1

Patient One B-100 provides Thiamine as Thiamine HCl to support healthy blood sugar metabolism and protection against advanced glycation and oxidative stress.

Riboflavin (B2

Readily absorbed in the small intestine but not stored by the body, Riboflavin is an essential B vitamin, playing a key role in the conversion of other B vitamins and in fat and glucose metabolism. Riboflavin is also an important nutrient for healthy eyesight and skin.

Niacin (as Niacinamide) B3

Niacin is an evidence-backed B vitamin that is most commonly used to support cardiovascular wellness. Research has suggested that niacin influences pathways associated with triglycerides and high-density lipoprotein (HDL) cholesterol, helping to maintain blood cholesterol levels that are already within normal range.

Pyridoxine (as Pyridoxine HCl) B6

Vitamin B6 has been shown to protect living lipids and proteins against glycation reactions. Aging results in the formation of advanced glycation end products (AGEs) throughout the body. By inhibiting AGE formation and working as a coenzyme in chemical reactions, B6 can support healthy nerves, eyes, and cardiovascular and kidney function.

Folate (as 5-MTHF)

The 5-MTHF (5-methyltetrahydrofolate) form of folate bypasses metabolic steps for enhanced folate bioavailability. Folic acid is well-known for its critical role in fetal development and also supports cardiovascular health, nervous system health, normal cell growth and energy production. It plays a role in brain energy, and helps to promote peak mental sharpness and clear memory.

Vitamin B12 (as Methylcobalamin)

Methylcobalamin is a highly bioactive form of vitamin B-12 and accounts for most B-12 circulating in plasma. Methylcobalamin B-12 supplies methyl groups for protein and DNA synthesis while supporting circulation, neurotransmitter production, and cellular energy production. B-12 also optimizes healthy homocysteine levels, promoting overall cardiovascular wellness.


Biotin has a beneficial effect on a number of structures and functions in the body. It is best known for its positive effect on hair and nails but also plays a role in supporting glucose metabolism by stimulating glucose-induced insulin secretion in pancreatic beta cells and by accelerating glucose metabolism in the liver. 

Pantothenic acid (Vitamin B5)

Pantothenic acid helps the body convert carbohydrates and fats into energy. It has been clinically proven to have a beneficial effect on lipid metabolism and adrenal immune function. It seems to positively affect triglyceride and lipoprotein levels by producing cystamine. B5 is also considered the “anti-stress” vitamin because it supports healthy adrenal cortex function and hormone synthesis. In addition, vitamin B5 may support digestive tract health, enhancing absorption of other nutrients.


A member of the vitamin B family, inositol contributes to the normal functioning of the central nervous system and brain health. Inositol is required for proper formation of cell membranes and and serves as part of the phosphatidylinositol second messenger system, supporting serotonin, norepinenephrine and cholinergic receptor function. As such, inositol may support healthy mood, emotional wellness and behavior, and ease occasional nervous tension.

Choline bitartrate

Choline is an essential nutrient that plays a vital role in maintaining the structural integrity of cell membranes. Choline is a precursor to acetylcholine, an important neurotransmitter involved in memory, muscle control and other essential functions of the body.

PABA (para-aminobenzoic acid)

PABA is a naturally occurring non-protein amino acid that works to improve the protein used in the body. It supports red blood cell formation, assists in the manufacture of folic acid in the intestines and also assists with breaking down of protein, the formation of red blood cells and maintaining intestinal flora. 


  • In a double-blind placebo-controlled trial, 205 subjects were randomized to receive either a combination of folic acid, vitamin B12, and vitamin B6, or placebo, for 6 months. At the end of the study, a significant benefit to cardiovascular function was observed in the treatment group compared to placebo. Plasma homocysteine levels were also significantly reduced in the treated group compared to placebo. (Schnyder et al, 2001)
  • A study of women volunteers in childbearing age evaluated how supplementation with either a B-12 supplement or B-12 plus folic acid supplement might influence plasma homocysteine levels. At study’s end, researchers suggested that supplementation was associated with significant reductions in plasma homocysteine, with the combination supplement of B-12 and folic acid providing greater reductions than the folic acid supplement alone.
  • A cohort study investigated the association between cognitive decline and B-12 and folate nutritional status. In the 1648 participants in the study, researchers found that low vitamin B-12 status was associated with more rapid cognitive decline.


  1. Willems FF, Boers GH, Blom HJ, et al. Pharmacokinetic study on the utilisation of 5-methyltetrahydrofolate and folic acid in patients with coronary artery disease. Br J Pharmacol. 2004 Mar;41(5):825-30 [PMID: 14769778]
  2. Schnyder G, Roffi M, Pin R, et al. N Engl J Med. 2001; 345:1593-1600.
  3. Halsted CH, Villanueva JA, Devlin AM. Folate deficiency, methionine metabolism, and alcoholic liver disease. Alcohol. 2002 Jul;27(3):169-72. [PMID: 12163145]
  4. Yakut M, Ustün Y, Kabaçam G, et al. Serum vitamin B(12) and folate status in patients with inflammatory bowel diseases. Eur J Intern Med. 2010 Aug;21(4):320-23. [PMID: 20603044]

Supplement Facts

Serving Size: 1 Tablet
Servings Per Container: 60
Amount Per Serving % Daily Value**

Thiamine (Vitamin B-1) (as Thiamine HCl)

100 mg 6,667%
Riboflavin (Vitamin B-2) 100 mg 5,882%
Niacin (Vitamin B-3) (as Niacinamide) 100 mg 500%
Vitamin B-6 (as Pyridoxine HCI) 100 mg 5,000%
Folate (as Calcium-L-5-methylhydrofolate) 100 mcg 25%
Vitamin B-12 (as Methylcobalamin) 100 mcg 1,667%
Biotin 100 mcg 33%
Pantothenic acid (as calcium pantothenate) 100 mg 1,000%
Inositol 100 mg
Choline (as bitartrate) 42 mg
PABA (as para-aminobenzoic acid) 30 mg
† Daily Value not established.
** Daily Values are based on a 2,000 calorie per day diet.

Suggested Use

Take 1 tablet daily as a dietary supplement, preferably with a meal, or as directed by a qualified health care professional.


Do not take with sulfonamide since PABA interferes with the activity of the drug. If pregnant, nursing, or taking any medications, consult doctor before use. Discontinue use and consult doctor if any adverse reactions occur.

B-100 Complex Label