Patient One Rhodiola Rosea supplies 350 mg of Rhodiola rosea root extract, standardized to provide beneficial concentrations of the root’s active constituents: 3% rosavins and 1% salidrosides. Also known as Arctic root or golden root, Rhodiola rosea is considered an adaptogenic herb, meaning that it acts in general, non-specific ways to increase resistance to stress, without disturbing normal biological functions. Extracts of this plant have been used for centuries and investigated for favorable properties in diverse areas of physiological function.
Of all the Rhodiola species, Rhodiola rosea has been the most widely studied for its role in reducing fatigue, increasing resistance to stress, decreasing depression, and improving mental and physical performance. By helping to enhance mood and reduce occasional episodes of nervousness and irritability, Rhodiola assists with improved ability to function under stressful conditions.
Rosavins and Salidrosides:
These bioactive phytochemicals in Rhodiola rosea root are classified as adaptogens, metabolic regulators that support the body’s ability to adapt to and counteract external stressors, including mental, physical and chemical factors. Rhodiola’s rosavins and salidrosides possess antioxidant and inflammation modulating activity, and most importantly, modulate the body’s stress hormone, cortisol. Studies support that Rhodiola rosea produces endocrine and reproductive effects, improving thyroid, thymus and adrenal gland function.
Numerous studies have shown the favorable effects of Rhodiola rosea on the central nervous system. It may positively affect neurotransmitters in the brain that are responsible for thinking, analyzing, evaluating, calculating, planning and remembering. It helps maintain normal levels of brain chemicals but, when they are already normal, Rhodiola will not further affect them. Rhodiola rosea also exhibits antioxidant effects, protecting the nervous system from oxidative damage caused by free radicals. Clinical and pharmacological studies have demonstrated the anti-stress and stimulant effects of Rhodiola. Multiple studies have shown Rhodiola rosea to increase physical work capacity and dramatically shorten the recovery time between periods of high-intensity exercise. Evidence also suggests it cardioprotective effects, providing an adaptive response for the heart during emotional and physical stress.
A study of 60 male and female volunteers between the ages of 20 and 55, conducted by the Uppsala University’s Department of Psychology in Uppsala, Sweden, evaluated the efficacy of Rhodiola rosea root extract for its adaptogenic effects and its ability to reduce fatigue. At the end of the 28-day study researchers found that the adaptogenic effects of a Rhodiola rosea root extract appeared to increase mental performance, optimize healthy mood, and reduce levels of the stress hormone cortisol.
A double-blind, crossover trial of a daily Rhodiola rosea root extract tablet and its efficacy in minimizing stress for 56 young, healthy physicians during two weeks of night duty was conducted by the Department of Neurology at Armenian State Medical University in Yerevan, Armenia. Researchers found that the cognitive and perceptive functions of physicians taking the Rhodiola rosea extract tablet were significantly improved. Researchers noted that rhodiola appeared to support healthy sleep patterns, emotional stability and healthy mood.
Russian studies suggest a positive role for Rhodiola in situations characterized by a decline in work performance, poor appetite, sleep disturbances, irritability, and fatigue
Another study showed that rhodiola rosea promoted endurance and coordination in athletes.
Olsson EM, von Schéele B, Panossian AG. A randomised, doubleblind, placebo-controlled, parallel-group study of the standardized extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009 Feb;75(2):105-12
Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue--a double blind crossover study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000 Oct;7(5):365-71.
Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011 Feb 15;18(4):235-44.
Schriner, S. E., Avanesian, A., Liu, Y., Luesch, H., and Jafari, M. Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radic. Biol Med 9-1-2009;47(5):577-584
Panossian, A., Wikman, G., and Sarris, J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17(7):481-493.
Zong, Y., Lowell, K., Ping, J. A., Che, C. T., Pezzuto, J. M., and Fong, H. H. Phenolic constituents of Rhodiola coccinea, a Tibetan folk medicine. Planta Med 1991;57(6):589.
Boon-Niermeijer, E.k., A. Van Den Berg, G. Wikman, and F.a.c. Wiegant. "Phyto-adaptogens Protect against Environmental Stress-induced Death of Embryos from the Freshwater Snail Lymnaea Stagnalis." Phytomedicine 7.5 (2000): 389-99. Phytomedicine. Web.
Afanas’ev SA, Alekseeva ED, Bardamova IB, et al. Cardiac contractile function following acute cooling of the body and the adaptogenic correction of its disorders. Bill Eksp Biol Med 1993;116:480-483. [Article in Russian]
Lee MW, Lee YA, Park HM, et al. Anti oxidative phenolic compounds from the roots of Rhodiola sachalinensis A. Bor. Arch Pharm Res 2000;23:455-458.
Ohsugi M, Fan W, Hase K, et al. Active- oxygen scavenging activity of traditional nourishing tonic herbal medicines and active constituents of Rhodiola sacra. J Ethnopharmacol 1999;67:111-119.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab or shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, rice, beef, or pork. Contains NO sugar and no artificial sweeteners, flavors, colors, or preservatives.
This product is free of ingredients derived from genetically modified organisms (GMOs).
Take 1 vegetarian capsule between meals as a dietary supplement or as directed by a qualified health care professional. It is recommended that it be taken early in the day to avoid potential interference with sleep in some individuals.
Long-term supplementation with adaptogens generally calls for repeating cycles characterized by short periods of adaptogen administration, followed by an interval with no supplementation.
Rhodiola rosea has been administered for periods ranging from as little as one day (acute administration) and up to four months. Periodic intervals of abstinence seems warranted when Rhodiola rosea is being used chronically.
Rhodiola may be contraindicated for those taking adrenergic-blocking and anti-arrhythmic medications. It should not be used in patients with bipolar disorder. If you are pregnant, nursing, or taking any medications, consult your doctor before use. Discontinue use and consult doctor if any adverse reactions occur.