Patient One Patient One Niacin 250 supplies a potent serving of niacin in an extended time-release form that gradually enters the bloodstream. Our time-release formulation supplies all of niacin’s benefits in a form that is gentle and safe. Because niacin releases histamine and causes capillary dilation which may cause a flushing of the skin, Patient One Niacin 250 is designed to maximize patient compliance by minimizing the “niacin flush."
Niacin is an evidence-backed B vitamin that is most commonly used to support cardiovascular wellness but has also shown additional benefits for circulatory wellness, blood health and nervous system health. Patient One Niacin 250 is an ideal foundation nutrient for your patients’ cardiovascular wellness and overall vitality.
Also known as vitamin B-3 or nicotinic acid, niacin is one of the most studied and documented nutrients for support of lipid levels already within normal range, especially high-density lipoprotein cholesterol (HDL-C). Niacin occurs in the body as two metabolically active coenzymes, NAD (nicotinaminde adenine dinucleotide) and NADP (NAD phosphate). The niacin coenzymes NAD and NADP have extensive roles in energy-related and biosynthetic metabolic processes. At least 200 enzymes depend on these niacin cofactors. The NAD-dependent enzymes are involved in mostly catabolic, oxidative reactions that release energy from carbohydrate, fat, protein and alcohol, whereas the NADP-dependent enzymes more commonly function in biosynthetic pathways of such compounds as fatty acids and steroid hormones.
Research has suggested that aside from its functions as NAD and NADP, niacin influences pathways associated with triglycerides and HDL cholesterol, helping to maintain blood cholesterol levels that are already within normal range. Niacin has been found to modulate lipoprotein biosynthesis in the liver, inhibit the release of free fatty acids from adipocytes, inhibit synthesis of apo B, induce lipoprotein lipase, and help maintain the structure and function of HDL by reducing the amount of apo A-1 broken down from HDL during hepatic processing.(1,2)
Niacin is the only B vitamin that can be synthesized in the liver from the amino acid tryptophan. (3-5) In its coenzyme forms, niacin is crucial to energy transfer reactions, particularly the metabolism of glucose, fat, and alcohol. 6,7) Niacin’s beneficial effects on blood lipids is well-documented.(8-20)