gluten free Non GMO Supplement

Patented blend supports vascular health, arterial flexibility and healthy circulation

  • Promotes vascular health / endothelial function
  • Optimizes arterial flexibility
  • Supports healthy circulation
  • Helps maintain blood pressure levels already within normal range

Discontinued Product

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Product Information Sheet (PDF)

Unique Properties

Patient One BP-One™ is a comprehensive nutrition support protocol for the management of healthy blood pressure and related systems. This formula supplies natural K2 and a proprietary blend of unique, cardio-supportive ingredients selected for their superior bioavailability and extensive scientific validation. BP-One supports nitric oxide production – dilating blood vessels for free-flowing circulation, arterial flexibility and optimal wellness.

Key Ingredients

VitaMK7™ menaquinone-7:

An ultra-pure form of vitamin K2, VitaMK7 exhibits the highest bioavailability and longest half-life in the blood. A benefit of longer half-life time of MK7 is that it is available longer than K1 for uptake by extrahepatic tissues to perform their function of moving cholesterol to the liver for excretion. K2 promotes arterial flexibility by modulating calcium metabolism – helping to keep the mineral in the skeletal system and out of the bloodstream. K2 promotes healthy circulation and helps maintain blood pressure that is already in a normal range.

Arginine Alphaketoglutarate:

Nitric oxide (NO) is important in maintaining the function of the interior lining of your arteries (endothelium). When NO is present in the inner lining of the blood vessels, it causes the surrounding smooth muscle to relax. This endothelium-dependent relaxation of the blood vessels then supports healthy blood flow. Arginine is a key precursor to nitric oxide, a vasodilator which promotes peak circulation and optimizes diverse aspects of circulatory-dependent wellness. Arginine promotes blood vessel health, optimizes circulation, and promotes blood vessel relaxation.


AmealPeptide is a clinically tested ingredient derived from casein (a milk protein). It is produced through a patented fermentation and enzymatic process that releases two key tripeptides, Valyl-Prolyl-Proline (VPP) and Isoleucyl-Prolyl-Proline (IPP), (made up of the three amino acid chains valine, proline and isoleucine). AmealPeptide provides VPP and IPP in concentrations not practical to achieve through the consumption of dairy products.

AmealPeptide works by inhibiting an enzyme that leads to the constriction of blood vessels. This vasodilating action is believed to be at least partly responsible for AmealPeptide’s clinically documented effect on blood pressure.

Supported by more than 30 published studies — including over a dozen double-blind, placebo-controlled human clinical trials — AmealPeptide helps maintain both systolic and diastolic blood pressure already within healthy limits and promotes arterial elasticity.

While it is made from milk protein, the lactose levels in AmealPeptide are undetectable (under .05%), so it is safe for those with lactose intolerance.

MegaNatural®-BP Grape Seed extract:

A grape seed extract standardized to 90% total Phenolics, MegaNatural-BP supplies beneficial compounds and antioxidants from a special seed blend from California-grown red and white wine grapes. With its unique structure and composition, including lower molecular weight oligomeric proanthocyanidins (OPCs), MegaNatural improves bioavailability and absorption – optimizing grape seed’s ability to stabilize blood vessels, promote circulation and influence blood pressure pathways. Research indicates that MegaNatural-BP activates the enzyme nitric oxide synthase (eNOS) to produce nitric oxide.

RC-NOS™ Rutaecarpine extract:

RC-NOS™ is rutaecarpine, an alkaloid extracted from the Traditional Chinese Wellness herb Evodia rutaecarpa (also called Wu-Chu-Yu). This bioactive is a vasorelaxant that has been shown to promote output of nitric oxide from endothelial cells, causing vascular smooth muscles to relax. RC-NOS optimizes arterial flexibility and healthy circulation and has been shown to inhibit platelet aggregation and to exhibit hypotensive action.


  • In a randomized, double-blind, placebo-controlled human clinical trial, 25 subject took either placebo, 150 mg MegaNatural®-BP daily or 300 mg MegaNatural-BP daily for 4 weeks. Blood samples showed MegaNatural-BP to be well-absorbed after a single dose, with a steep rise in polyphenols 90 minutes after ingestion. After four weeks, both dosages of MegaNatural®-BP were found to help maintain blood pressure levels (both systolic and diastolic) within the normal range. In addition, both dosages decreased levels of oxidized LDL cholesterol.
  • In a placebo-controlled study of 54 participants, subjects received 2 or 4 grams of L-arginine in supplement form 3 times daily over a period of 4 weeks. At study’s end, researchers found that both systolic and diastolic blood pressure was significantly lower after four weeks of patients receiving 12 g of L-arginine daily, leading researchers to suggest a strong association between L-arginine supplementation and blood pressure reduction.
  • A meta-analysis of 12 trials totaling 623 participants evaluated the relationship between milk peptide and blood pressure. Analysis of the 12 trials revealed significant decreases of 4.8 mmHg in systolic BP and 2.2 mmHg in diastolic BP, leading researchers to suggest that milk-derived tripeptides appear to support blood pressure in normal range.


  1. Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T. E ect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009; 58:1743-1746.
  2. Ast, J., Jablecka, A., Bogdanski, P., Smolarek, I., Krauss, H., and Chmara, E. Evaluation of the antihypertensive effect of L-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring. Med.Sci.Monit. 2010;16(5):CR266-CR271.
  3. Bai, Y., Sun, L., Yang, T., Sun, K., Chen, J., and Hui, R. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials. Am J Clin.Nutr. 2009;89(1):77-84.
  4. Xu JY, Qin LQ, Wang PY, Li W, Chang C. Effect of milk tripeptides on blood pressure: a meta-analysis of randomized controlled trials. Nutrition. 2008 Oct;24(10):933-40. Epub 2008 Jun 17.
  5. Fitzpatrick, D. F., Hirschfield, S. L., and Coffey, R. G. Endotheliumdependent vasorelaxing activity of wine and other grape products. Am J Physiol 1993;265(2 Pt 2):H774-H778.
  6. Sheu JR, et al. Pharmacalogical Effects of Rutaecarpine, An Alkaloid Isolated from Evodia rutaecarpa. Cardiovascular Drug Reviews Vol. 17, No. 3, pp. 237-245. 1999.

Supplement Facts

Serving Size: 2 Tablets
Servings Per Container: 30
Amount Per Serving % Daily Value**
Natural Vitamin K-2 (as VitaMK7™menaquinone-7) 30 mcg 38%

Folate [as Quatrefolic® (6S)-5 Methyltetrahydrofolic acid equivalent to 1600 mcg of (6S)-5 Methyltetrahyrdofolic acid, Glucosamine salt]

800 mcg 200%
Vitamin B-12 (as methylcobalamin) 250 mcg 4167%
Proprietary Blend

Arginine Alphaketoglutarate, AmealPeptide® E Lactotripeptides (IPP, VPP), MegaNatural® BP Grape Seed extract (Vitis vinifera) [Standardized to 90% Total Phenolics as Gallic Acid Equivalents], RC-NOS™ Rutaecarpine extract (Evodia rutaecarpa) (fruit)

1435 mg
† Daily Value not established.
** Daily Values are based on a 2,000 calorie per day diet.

Suggested Use

Take 2 tablets once daily as a dietary supplement, or as directed by a qualified health care professional.


Avoid this product if you have a history of bleeding disorder, acute myocardial infarction, stomach ulcers or esophageal reflux. Use with caution if you use blood thinners. If you are pregnant, nursing, or taking any medications, consult your doctor before use. Discontinue use and consult doctor if any adverse reactions occur. The lactose levels in AmealPeptide are undetectable (under .05%), so it is safe for those with lactose intolerance.

BP-One™ Label