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OpticOne™

OpticOne™
gluten free vegetarian vegetable capsule Non GMO Supplement

Nutritional support for optic nerve health and optimal eyesight function

  • Supports proper flow of eye fluid
  • Decreases intraocular pressure
  • Helps maintain visual acuity
  • Eases eye strain
  • Helps block damaging free radicals
  • Supports vascular function

CPG Choice Award Winner 2014
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Product Information Sheet (PDF)

UNIQUE PROPERTIES 

Patient One OpticOne™ supplies a comprehensive blend of over 15 synergistic nutrients known to protect and support healthy optic nerve function. OpticOne was formulated to help regulate ocular fluid and blood flow and promote reduced intraocular pressure (IOP). Created in conjunction with ophthalmologists, this research-based formula allows for increased intake of targeted ocular antioxidants that promote a healthy retina, lens and optimal eyesight function. 

 

KEY INGREDIENTS 

Vitamins A, C & E are antioxidants that work together to promote eye health. Evidence suggests that oxidative stress plays a role in POAG. Vitamin A binds to the rods (rhodopsin) and cones (iodopsin) in the retina, giving vitamin A its alternate name, retinol. Vitamin C has been shown to regenerate Vitamin E in the retina and in rod segments by reducing the oxidized portion of the vitamin E molecule. Vitamin C also forms the connective tissue of the cornea and helps to prevent this tissue from absorbing UV radiation. Additionally, vitamin C has been shown to lower eye pressure. A study on glaucoma patients found that Vitamin E helped to prevent visual field loss. 

Vitamin B12 is believed to preserve myelin, which insulates nerve cells in the eyes. Clinical data supports its ability to preserve eyesight and provide a protective effect on the optic nerve. 

Magnesium blocks the entry of calcium into cells and produces relaxation of constricted blood vessels in the eyes, which is beneficial for optic nerve health. Low magnesium may be a factor in vasopastic migraine and supplementing has been shown to be beneficial.

Chromium has been found to enable the eye to focus without straining and helps reduce intraocular pressure. Chromium deficiency can cause a decrease in utilization of glucose, which is necessary for the muscles of the eyes to focus and function optimally. 

Alpha Lipoic Acid can regenerate vitamin C and glutathione and can recycle vitamin E. It prevents or impedes cell oxidation or destruction by free radicals. It has been researched for its role in enhancing color, visual fields and visual sensitivity, improving visual function and reducing damage in the eyes. 

Ginkgo biloba has been used to improve blood flow in small capillaries such as those found in the eye. Studies show that ginkgo is a powerful antioxidant and membrane stabilizer that can slow down retinal deterioration, resulting in increased visual acuity. Clinical research supports gingko biloba’s role in impeding the development of glaucoma, lowering IOP, improving mitochondrial function, and maintaining balance in the blood circulation. 

Grapeseed extract has been found to improve blood flow in the eye, support capillary integrity, and ward off free-radical damage that can cause harm to the eyes. Studies have found that taking grapeseed extract daily can ease eyestrain and enhance perception of contrast. 

Bilberry extract for eye health dates back as far as World War II. Bilberry jam, which was made from Vaccinium myrtillus berries, was given to the Royal Air Force pilots on night flights to improve their eyesight. Standardized bilberry extract plays an important role in improving retinal sensitivity. Bilberry is a rich, natural source of the anthocyanins known for protecting capillaries from free radical damage. Animal studies have shown protective benefits against early stage cataracts or macular degeneration when bilberry extract was added to diet. Research supports the use of ginkgo biloba in combination with bilberry anthocyanins for improved visual function in patients with glaucoma. Additionally, combining grapeseed and bilberry extracts has been clinically shown to improve ocular blood flow and decrease IOP in ocular hypertension.

Quercetin is a bioflavanoid that protects the eye from sun radiation. It reduces the leakage from damaged small blood vessels in the retina. It also may help protect against cataracts by blocking sorbitol accumulation in the eye. This may be especially helpful for maintaining healthy blood sugar levels. Quercetin inhibits oxidative damage in the lens and inhibits aldose reductase, the enzyme considered key to maintaining the clarity of the lens.

L-Taurine, found in the highest concentrations in the retina, acts as an antioxidant in the eye and appears to be a regulator of neuronal excitability, fluid regulation, detoxification, and membrane stabilization. L-Taurine plays a role in rhodopsin regeneration, which is necessary for night vision. It is essential to the retinal pigment epithelium and the photoreceptors where it is found at levels ten times higher than other amino acids. L-Taurine helps to transport nutrients across cell membranes and assists in the elimination of potentially toxic substances.

CoQ10 defends against oxidative damage and is associated with improved visual function in people with early Age-Related Macular Degeneration. 

N-Acetyl-L-Cysteine (NAC) boosts the endogenous levels of glutathione, a key ocular antioxidant. As people age, levels of glutathione drop. Individuals with cataracts were found to have one-tenth the amount of glutathione as those without cataracts. NAC protects the tear film by increasing glutathione levels in the eye, which prevents the oxidation of phosphatidylethanolamine and sphingomyelin.

Lutein is a vital component of the macula and may provide antioxidant protection to this area of the retina. Lutein also protects the macula from damaging blue light. Low levels of lutein are associated with macular degeneration and cataracts. Visual acuity and contrast sensitivity were improved with lutein supplementation as compared to placebo in a prospective study of 90 patients with AMD.

References

  1. Gottschall-Pass KT, et al. Oscillatory potentials and light microscopic changes demonstrate an interaction between zinc and taurine in the developing rat retina. J Nutr. 1997 Jun;127(6):1206-13 [PMID: 9187637]
  2. Rahman MM, et al. Superoxide radical- and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism. Free Radic Res. 2006 Sep;40(9):993-1002 [PMID: 17015281]
  3. Cornish KM, Williamson G, Sanderson J. Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. Free Radic Biol Med. 2002 Jul 1;33(1):63-70 [PMID: 12086683]
  4. Alves-Rodrigues A, Shao A The science behind lutein. Toxicol Lett. 2004 Apr 15;150(1):57-83. [PMID: 15068825]
  5. Cybulska-Heinrich AK, et al. Ginkgo biloba: An adjunctive therapy for progressive normal and high tension glaucoma. Molecular Vision. 2012 Feb 9; 18:390-402.
  6. Yang H, et al. Protective effect of grape seed extract against oxidative stress-induced cell death in a staurosporine-differentiated retinal glanglion cell line. Current Eye Research. 2012; 37(4):339-344.
  7. Stringham JM, et al. The influence of dietary lutein and zeaxanthin on visual performance. J Food Sci. 2010; 75(1):R24-R29.
  8. Rahman M, et al. Superoxide radical- and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism. Free Radical Research. Sept 2006; 40(9):993-1002.

Supplement Facts

Serving Size: 3 Capsules
Servings Per Container: 60
Amount Per Serving % Daily Value**

Vitamin A (as beta carotene)

3000 IU 60%

Vitamin C (as ascorbic acid)

250 mg 417%

Vitamin E (as d-alpha tocopheryl succinate)

30 IU 100%

Folate (as folic acid)

400 mcg 100%

Vitamin B-12 (as methylcobalamin)

6 mcg 100%

Magnesium (as magnesium oxide)

120 mg 30%
Selenium (as L-selenomethionine) 100 mcg 143%
Chromium (as Chromium picolinate) 150 mcg 125%
Alpha lipoic acid 150 mg
Ginkgo biloba

(leaf) extract [Standardized for 24% ginkgoflavonglycosides and 6% total terpene lactones]

120 mg
Grapeseed extract

(Vitis vinifera) (inner core of fruit) [Standardized for 95% proanthocyanidins]

200 mg
Bilberry extract

(Vaccinium myrtillus) (berry) [Standardized for 25% Anthocyanins]

150 mg
Quercetin dihydrate 100 mg
L-Taurine 300 mg
Coenzyme Q10

(as ubidicarenone)

30 mg
N-Acetyl-L-Cysteine 150 mg
Lutein

[from Marigold flowers (Tagates erecta) FloraGLO®]  

10 mg
Flaxseed bran

(Linum usitatissimum) [Providing a minimum 3% Lignans]

150 mg
† Daily Value not established.
** Daily Values are based on a 2,000 calorie per day diet.


Suggested Use

Take 3 capsules daily as a dietary supplement, preferably with a meal, or as directed by a qualified healthcare professional. May take in divided doses.

Warnings

If you are pregnant, lactating, or taking any medications, consult your doctor before use. Use with caution if you take blood thinners, as Ginkgo biloba may affect platelet aggregation and the combination could raise the risk of increased bleeding. Discontinue use and consult doctor if any adverse reactions occur.

 
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