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Melatonin 3 mg Gradual Release

Melatonin 3 mg Gradual Release
gluten free vegetable capsule Non GMO Supplement

Nutritional support for natural sleep patterns and immune system health

  • Helps the body regulate wake/sleep cycle
  • Promotes onset of sleep
  • Supports sleep quality
  • Improves antioxidant and immune system activity
  • Presented in a gradual release capsule

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Product Information Sheet (PDF)

UNIQUE PROPERTIES 

A natural hormone synthesized from the amino acid tryptophan by the pineal gland, melatonin acts as a powerful regulator of sleep and the body’s daily rhythmic cycles. Melatonin is also an important antioxidant, acting as an effective scavenger of free radicals. Many factors can cause a decrease in natural melatonin levels, including aging—with some older adults making very small amounts or none at all— insufficient exposure to natural light, and certain medications. As melatonin is naturally activated by darkness and depressed by light, irregular schedules can disrupt its production. Supplementation with melatonin has proven to be beneficial for the elderly, those with shift work hours or suffering from jet lag, and people who have difficulty falling asleep. 

 

KEY INGREDIENTS 

Melatonin: 

Patient One Melatonin plays an important role in regulating the body’s daily and annual biological rhythms, the sleep/wake cycle. When taken before the onset of the natural melatonin secretion, melatonin can promote sleep. It is believed that melatonin potentiates the effects of gamma-aminobutyric acid (GABA) via direct interaction with GABA receptors, resulting in relaxation. Researchers have indicated that melatonin supports the quality of sleep as it relates to falling asleep, sleep efficiency (percent of healthy sleep to total time in bed), and awakening. 

Studies suggest that melatonin also supports antioxidant activity, cardiovascular health and immune function. Intracellular melatonin is concentrated in the mitochondria, a major site of oxidative metabolism. Melatonin has also been found to support extracellular antioxidant activity, support glutathione production, and stimulate production of intracellular antioxidant enzymes. 

Research

  • A study investigating the effect of melatonin treatment on melatonin-deficient insomnia in the elderly suggests that melatonin replacement therapy, using a low dosage of melatonin (1 or 2 mg), has specific effects on sleep initiation and maintenance in these patients. A 1-week treatment of 2 mg sustained-released melatonin was effective on sleep maintenance (i.e. sleep efficiency and activity level) of elderly insomniacs. This study suggests that melatonin appears to have a beneficial effect when administered in the form of sustained-release tablets and should be used over the long term. (1)
  • A randomized, double-blind, placebo-controlled trial was performed on humans with unselected neuropsychiatric sleep disorders and reduced REM sleep duration to evaluate the effects of exogenous melatonin on disturbed REM sleep. The results of the study show that melatonin was significantly more effective than placebo. Patients on melatonin experienced significant increases in REM sleep percentage and improvements in subjective measures of daytime dysfunction as well as clinical global impression score.(3)

References

  1. Haimov I, Lavie P, Laudon M, et al. Melatonin replacement therapy of elderly insomniacs. Sleep. 1995 Sep;18(7):598-603.
  2. van Geijlswijk IM, Korzilius HP, Smits MG. The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep. 2010 Dec;33(12):1605-14.
  3. Kunz D, Mahlberg R, Müller C, et al. Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. J Clin Endocrinol Metab 2004 Jan;89(1):128-34.
  4. Pandi-Perumal SR, Srinivasan V, Spence DW, et al. Role of the melatonin system in the control of sleep: therapeutic implications. CNS Drugs. 2007;21(12):995-1018.
  5. Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev. 2002;(2):CD001520. Review.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving % Daily Value**
Melatonin (Gradual Release) 3 mg
† Daily Value not established.


Suggested Use

Take 1 vegetable capsule 1/2 hour to 1 hour before bedtime as a dietary supplement or as directed by a qualified health care professional.

Warnings

Not to be taken by pregnant or lactating women. Not intended for children. May have sedating effects and is for bedtime use only. Use may be contraindicated in depression, seasonal affective disorder, schizophrenia, autoimmune disease, asthma and for individuals taking MAOIs or corticosteroids. Discontinue use and consult doctor if any adverse reactions occur.

 
Melatonin 3 mg Gradual Release Label