Patient One cognitive support supplements are designed to optimize multiple aspects of cognitive health by promoting cerebral blood flow, neutralizing free radicals in the brain, energizing brain cells and supporting production of neurotransmitters. Our cognitive support MediNutritionals include key phospholipid building blocks for the formation of healthy new brain cells.
Comprehensive, multi-modal support for cognitive performance, supplying nutrition for neurogenesis, cerebral circulation and antioxidant activity in the brain
Patient One NeuroOne™ supplies advanced medinutritional support for focus, memory and mood. NeuroOne activates serotonin (5HT-1a) receptors, promotes healthy cerebral blood flow, supports neurotransmitter production, provides antioxidant protection against brain oxidative stress, and supplies vital building block nutrition for neurogenesis – the creation of new brain cells. NeuroOne is an ideal formula for optimizing cognitive function, whether supporting mental focus and attention span or promoting bright mood and addressing mild memory problems associated with aging.
Sharp-PS® supplies high purityphosphatidylserine (PS), derived from soy through a patented process. PS is a structural component of cells that is found in all biological membranes of plants, animals and other forms of life. The human body contains about 30g of phosphatidylserine, about half of which is found in the brain.
This orthomolecule is a raw material in neurogenesis, the creation of new brain cells. PS promotes brain cellular energy and catalyzes neurotransmitter production, promoting communication between brain cells. Pre-clinical and clinical studies support improved cognitive function with oral administration of phosphatidylserine.
Because neuronal cells do not readily regenerate, it is important that these cells have a superior survival mechanism. High levels of PS in neuronal membranes were shown to be important for neuronal survival by facilitating several important cellular processes. Maintaining PS levels in neuronal tissues has been associated with normal and efficient signal transduction processes, efficient neuronal glucose consumption and other biological pathways that are crucial for normal and healthy cognitive and mental functions.
Glycerophosphatidylcholine (GPC) is a naturally occurring phospholipid and essential brain nutrient that is a bioavailable source of choline and a precursor to the neurotransmitter acetylcholine. It is found in abundant concentrations when we are born, particularly in brain tissue. As a normal part of the aging process, levels in the cell decrease over time. In the diet, GPC is normally presented in low amounts, in food such as milk, eggs and meat. NeuroOne supplies Sharp-GPC, high purity, soy-derived phosphatidylcholine that boosts acetylcholine levels in the brain to optimize central neurotransmission, promoting clear cognition and sharp memory. It has also been studied for its support in head trauma recovery.
The neurotransmitter serotonin is key for higher-level cognitive function including working memory and measures of focus and mood. Brewed concoctions containing Bacopa monnieri (Brahmi) has long been a part of daily life for children and adults in India. Bacopa extracts are widely used in integrative medicine to assist with cognitive function. However, not all Bacopa compounds are equally active, and not all extracts are the same.
BaCognize® extract is a proprietary, concentrated, clinically researched extract of Bacopa monnieri which has undergone rigorous scientific validation. Clinical research indicates Bacopa offers broad benefits for cognitive health, linked to three major neuro-supportive mechanisms: neurotransmitter receptor binding activity, antioxidant capacity and anti-inflammatory activity.
Standardized to 45% baccosides, this extract of Bacopa monnieri has shown potent activity at the site of human serotonin (5HT-1a) receptors and has been shown to promote aspects of cognitive performance, memory and mood. It may help address fuzzy thinking and forgetfulness.
Ginkgo Biloba & Vinpocetine:
Neurons are completely reliant on a continuous supply of oxygen and glucose, which is delivered to them by the blood. Neurological tissue is especially vulnerable to oxidative stress because of its high demand for oxygen, high levels of polyunsaturated fatty acids in neural membrane phospholipids, and low antioxidant defenses. Both of these antioxidant botanicals are vasodilators that improve cerebral blood flow and cerebral oxygenation, supporting healthy brain energy and optimizing delivery of NeuroOne’s neuronutrient complex. Ginkgo also supports acetylcholine availability.
Botanical Neuro Complex:
With grapeseed, trans-resveratrol, quercetin, ginger, and Perluxan® hops, NeuroOne’s Botanical Neuro Complex supplies dual-action nutritional support for key factors associated with cognitive decline: It modulates brain inflammation and supplies abundant antioxidant activity to neutralize brain oxidative stress.
Soy lecithin contains a mixture of phospholipids isolated from soybeans that are essential for every cell of the human body. Lecithin is an integral part of the cell membranes, the protective sheaths surrounding the brain, muscle and nerve cells and also plays a vital role in maintaining brain functions. Lecithin provides the phospholipid choline, a precursor to acetylcholine, an important neurotransmitter for normal brain functioning that is associated with improved memory. Various studies support the use of lecithin as an adjunctive therapy for cognitive function.
Nathan, P.J., Tanner, S., Lloyd, J., Harrison, B., Curran, L., Oliver, C., and Stough, C. "Effects of a Combined Extract of Ginkgo biloba and Bacopa monniera on Cognitive Function in Healthy Humans." Human Psychopharmacol. Clin. Exp. 19: 91-96, 2004.
Efficacy of BACOGNIZE® Extract on Memory in Medical Students: A randomized, double blind, placebo-controlled, non-crossover trial, Psychology Department of Lady Amritabai Daga College for Women, Nagpur, India.
Hall, B., Burnett, A., Halley, C., Christians, A., Parker, L.A., Medora, R., and Parker, K.K. "Pharmacology of Bacopa at 5HT1a and 5HT2a Receptors." Am. Soc. Pharmacog. Absts. P:85, 83, 2005.
Roodenrys, S., Booth, D., Bulzomi, S., Phipps, A., Micallef, C., and Smoker, J. "Chronic Effects of Brahmi (Bacopa monnieri) on Human Memory." Neuropsychopharmacology 27 (2): 279?281, 2002.
Parietti L. Amenta F, Gallai V. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data. Mech Aging Dev 2001; 122:2045-55.
Fernandez-Murray JP, McMaster CR. Glylcerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway. J Biol Chem 2005;280:38290-6.
DeJesus Moreno. Cognitive improvement in milk to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multi center, double-blind, randomized, placebo-controlled trial. Clin Ther 2003;25:178-93.
Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer’s Disease. Psychopharmacol Bull. 1992;28(1):61-6.
Singh, M. Essential fatty acids, DHA and human brain, Indian Journal of Pediatrics, 2005; Vol.72, Issue 3, pp. 239-242.
Barberger-Gateau P, Letenneur L, et al. Fish, meat, and risk of dementia: cohort study. British Medical Journal 2002; 325: 932-933.
Schaefer E, et al. Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer’s Disease. Arch Neurol. 2006;63:1545-1550.
Tabaton M, Schenone A, Mansard GL, Italian multicenter study of dementia: a pathologically verified case of Alzheimer disease, Ital J Neurol Sci 7(1):161-163, 1986
Chrissobolis S, Faraci FM. The role of oxidative stress and NADPH oxidase in cerebrovascular disease. Trends Mol Med. 2008 Nov;14(11):495-502. [PMID: 18929509]
Horvath B, Marton Z, Halmosi R, et al. In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine. Clin Neuropharmacol. 2002 Jan- Feb;25(1):37-42. [PMID: 11852295]
Deshmukh R, Sharma V, Mehan S, et al. Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine—a PDE1 inhibitor. Eur J Pharmacol. 2009 Oct;620(1-3):49-56. [PMID: 19699735]
Hadjiev D. Asymptomatic ischemic cerebrovascular disorders and neuroprotection with vinpocetine. Ideggyogy Sz. 2003 May;56(5-6):166-72. [PMID: 12861957]
Muravyov AV, Yakusevich VV, Chuchkanov FA, et al. Hemorheological efficiency of drugs, targeting on intracellular phosphodiesterase activity: in vitro study. Clin Hemorheol Microcirc. 2007;36(4):327-34. [PMID: 17502703]
Vinpocetine. Monograph. Altern Med Rev. 2002 Jun;7(3):240-43. [PMID: 12126465]
Serving Size: 2 Capsules
Servings Per Container: 30
Amount Per Serving
% Daily Value**
Calories from Fat
Vitamin B-12 (as methylcobalamin)
GlyceroPhosphatidylCholine (as Sharp-GPC™, from soy)
Phosphatidylserine (as Sharp-PS® Phosphatidylserine, from soy)
** Daily Values are based on a 2,000 calorie per day diet.
Vegetable cellulose, silicon dioxide, maltodextrin, and chlorophyll.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab or shrimp), tree nuts, wheat, yeast, gluten, rice, beef, or pork. Contains NO sugar and no artificial sweeteners, flavors, colors, or preservatives.
Sharp-PS® and Sharp-GPC™ are registered trademarks of Enzymotec Ltd. Bacognize® is a registered trademark of Verdure Sciences Inc. Perluxan® is a registered trademark of Pharmachem Laboratories. Alcolec® is a registered trademark of American Lecithin Company.
Take two vegetarian capsules with food once daily, preferably in the morning, as a dietary supplement or as directed by a qualified health care professional.
This product should not be used by women who are pregnant or may become pregnant. If you are taking any medications, consult your doctor before use. Use with caution if you take blood thinners as Ginkgo biloba may affect platelet aggregation. Discontinue use and consult doctor if any adverse reactions occur.