NAC 600 mg

Support for immune system function, respiratory health, detoxification and cardiac function

Enhances glutathione production
Provides mucolytic and antioxidant action
Promotes homocysteine metabolism
Supports healthy lung tissue
Promotes respiratory and immune health
Supports heavy metal detoxification

Patient One NAC supplies 600 mg per capsule of the amino acid N-Acetyl-L-Cysteine, which is known for diverse clinical uses.

Specific components of the immune system rely on NAC to function properly. NAC supports respiratory and immune health by promoting normal mucus viscosity. When mucus thickens, it can become hard to expel. Because of its sulfur content, NAC is able to disrupt disulfide bonds, thinning the mucus so that mucus, together with any trapped bacteria and particles, are more easily expelled from the lungs. It also helps with the rebuilding of lung tissue.

NAC plays a key role in phase II detoxification. It is a precursor of the intracellular antioxidant glutathione. Due to its function of enhancing glutathione production and utilization, NAC is recognized as an effective means of increasing circulating levels of glutathione in the body. NAC supports heavy metal detoxification. Several animal studies found that NAC administration may help to reduce mercury and cadmium accumulation in the kidneys and liver and/or to moderate the effects of these metals in these tissues.

A source of the amino acid L-cysteine, NAC offers further support for overall cardiovascular wellness. Breaking disulfide bonds as described above may also be the same mechanism by which NAC promotes lower homocysteine and improved endothelial function. NAC is believed to block homocysteine formation at plasma protein binding sites while encouraging efficient elimination of homocysteine via urinary excretion.

References

Keogh JP, Steffen B, Siegers CP. Cytotoxicity of heavy metals in the human small intestinal epithelial cell line I-407: the role of glutathione. J Toxicol Environ Health. 1994 Nov;43(3):351-9. [PMID: 7966443]
Ottenwalder H, Simon P. Differential effect of N-acetylcysteine on excretion of the metals Hg, Cd, Pb and Au. Arch Toxicol. 1987 Jul;60(5):401-2. [PMID: 3662815]
Krinsky DL, LaValle JB, Hawkins EB, et al. Natural Therapeutics Pocket Guide. 2nd ed. Hudson (OH): Lexi-Comp; 2003.
Grandjean EM, Berthet P, Ruffmann R, Leuenberger P. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clin Ther. 2000 Feb 22(2):209-21. [PMID: 10743980]
Witschi A, et al. The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43:667-9. [PMID: 1362956]
Atkuri KR, Mantovani JJ, Herzenberg LA, et al. N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9. Review. [PMID: 17602868]

Supplement Facts

Serving Size: 1 capsule
Servings Per Container: 90
Amount Per Serving	% Daily Value**
N-Acetyl-L-Cysteine	600	mg	†

† Daily Value not established.
** Daily Values are based on a 2,000 calorie per day diet.
Other Ingredients: vegetable cellulose (capsule), rice flour, l-leucine
Contains: This product is a sulfur-containing compound and may emit a sulfur odor.
FREE OF: milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast and gluten. This product is free of ingredients derived from GMOs.

Suggested Use

Take 1 capsule 1 to 3 times daily as a dietary supplement, between meals, or as directed by a healthcare professional.

Warnings

Consult doctor before use if you are taking nitroglycerin or other medications, or are pregnant or nursing. Discontinue use and consult doctor if any adverse reactions occur.