Patient One cognitive support supplements are designed to optimize multiple aspects of cognitive health by promoting cerebral blood flow, neutralizing free radicals in the brain, energizing brain cells and supporting production of neurotransmitters. Our cognitive support MediNutritionals include key phospholipid building blocks for the formation of healthy new brain cells.
Patient One Cogni-Sharp™ provides a complementary blend of mushrooms and herbs that support focus, mental acuity and brain function at all ages.
This formula promotes sharp cognition, supporting concentration and attention span, addressing memory difficulties and mild forgetfulness, and promoting a healthy mood.
Brain Performance Blend:
Our comprehensive blend featuring mushrooms Cordyceps and Lion’s mane, along with brain-supporting botanicals Ginkgo biloba, Gotu kola, Bacopa monnieri, Rhodiola, Rosemary and Turmeric, supports healthy neurological function and can help promote a clear mind and normal memory.
The herbal extracts in Cogni-Sharp are widely used in integrative medicine to assist with cognitive function. Bacopa monnieri has shown potent activity at the site of human serotonin (5HT-1a) receptors and has been shown to promote various aspects of cognitive performance, information processing, memory and mood. It may help address fuzzy thinking and forgetfulness.
Gotu kola and ginkgo biloba help to support healthy production of neurotransmitters which contribute to normal mood. Gotu kola has been used to support healthy circulation in the brain. Likewise, ginkgo promotes enhanced cerebral blood flow and healthy red blood cell and platelet function in the brain. It is a free radical scavenger that provides antioxidant defense.
Curcuminoids (from turmeric) and rosemary are also included for their antioxidant properties. Turmeric curcumin helps protect neurons from oxidative stress and supports healthy vascular tissue in the brain. Rosemary diterpenes have also been shown to inhibit neuronal cell death.
Rhodiola is a brain adaptogen that helps balance the brain chemicals serotonin, norepinephrine and dopamine without causing drowsiness or fatigue. It helps moderate occasional mental and physical stress, promoting a healthy mood. Rhodiola supports learning, focus and memory.
Lion’s mane, a nootropic mushroom traditionally used to support nervous system health, promotes mental clarity, focus, and memory.
Achete de Souza G, de Marqui SV, Matias JN, Guiguer EL, Barbalho SM. Effects of Ginkgo biloba on Diseases Related to Oxidative Stress. Planta Med. 2020 Apr;86(6):376-386. doi: 10.1055/a-1109-3405.
Diamond BJ, Shiflett SC, Feiwel N, Matheis RJ, Noskin O, Richards JA, Schoenberger NE. Ginkgo biloba extract: mechanisms and clinical indications. Arch Phys Med Rehabil. 2000 May;81(5):668-78. doi: 10.1016/s0003-9993(00)90052-2.
Hall, B., Burnett, A., Halley, C., Christians, A., Parker, L.A., Medora, R., and Parker, K.K. "Pharmacology of Bacopa at 5HT1a and 5HT2a Receptors." Am. Soc. Pharmacog. Absts. P:85, 83, 2005.
Kennedy DO. Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance. Sports Med. 2019 Feb;49(Suppl 1):39-58. doi: 10.1007/s40279-018-1007-0.
Kim YO, Kim HJ, Abu-Taweel GM, Oh J, Sung GH. Neuroprotective and therapeutic effect of Cordyceps militaris on ischemia-induced neuronal death and cognitive impairments. Saudi J Biol Sci. 2019 Nov;26(7):1352-1357. doi: 10.1016/j.sjbs.2018.08.011. Epub 2018 Aug 17.
Lewis JE, Poles J, Shaw DP, Karhu E, Khan SA, Lyons AE, Sacco SB, McDaniel HR. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. J Clin Transl Res. 2021 Aug 4;7(4):575-620.
Nathan, P.J., Tanner, S., Lloyd, J., Harrison, B., Curran, L., Oliver, C., and Stough, C. "Effects of a Combined Extract of Ginkgo biloba and Bacopa monniera on Cognitive Function in Healthy Humans." Human Psychopharmacol. Clin. Exp. 19: 91-96, 2004.
Roodenrys, S., Booth, D., Bulzomi, S., Phipps, A., Micallef, C., and Smoker, J. "Chronic Effects of Brahmi (Bacopa monnieri) on Human Memory." Neuropsychopharmacology 27 (2): 279?281, 2002.
Sangiovanni E, Brivio P, Dell'Agli M, Calabrese F. Botanicals as Modulators of Neuroplasticity: Focus on BDNF. Neural Plast. 2017;2017:5965371. doi: 10.1155/2017/5965371. Epub 2017 Dec 31.
Sbrini G, Brivio P, Fumagalli M, Giavarini F, Caruso D, Racagni G, Dell'Agli M, Sangiovanni E, Calabrese F. Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex. Nutrients. 2020 Jan 29;12(2):355. doi: 10.3390/nu12020355.
Sun B, Wu L, Wu Y, et al. Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review. Front Pharmacol. 2020;11:568032. Published 2020 Sep 4. doi:10.3389/fphar.2020.568032
Yuan G, An L, Sun Y, Xu G, Du P. Improvement of Learning and Memory Induced by Cordyceps Polypeptide Treatment and the Underlying Mechanism. Evid Based Complement Alternat Med. 2018 Mar 15;2018:9419264. doi: 10.1155/2018/9419264.
Zaidi, Dr.Kamal. (2017). The health benefits of Cordyceps militaris - A review. Kavaka. 48. 27-32.
Serving Size: 2 capsules
Servings Per Container: 30
Amount Per Serving
% Daily Value**
Brain Performance Blend
Cordyceps militaris mycelia†, lion’s mane mycelia and fruiting body†, ginkgo leaf†, gotu kola herb†, bacopa herb†, rhodiola root†, rosemary herb†, turmeric root†
† Daily Value not established.
vegetable capsule (pullulan), organic myceliated brown rice
Free of milk, egg, fish, peanuts, crustacean shellfish, soy, tree nuts, wheat, yeast and gluten. Free of ingredients derived from GMOs.
Take 2 capsules once daily as a dietary supplement, or as directed by your health practitioner. Store in a cool, dry place.
If you are pregnant, nursing, or taking any medications, consult your health practitioner before use. Discontinue use and consult your health practitioner if any adverse reactions occur. Keep out of reach of children.