Patient One Enflamen™ mediates activity of pro-inflammatory prostaglandins and enzymes with a broad range of standardized botanical extracts, antioxidants and omega-3 fish oil. Enflamen’s comprehensive nutritional support promotes a healthy inflammatory response throughout the body while promoting soothing comfort in the joints and connective tissue. Additionally, Enflamen supports effective functioning of macrophage immune cells and enhances the body’s natural defense system.
Key Ingredients
Omega-3 Fish Oil: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) influence production of beneficial eicosanoids that support a healthy inflammatory response and are also believed to act upon gene expression and intracellular signaling pathways to promote normal immune responses. Fish oil also promotes optimal joint function and supports healthy connective tissue.
Meriva® Turmeric Phytosome™: It's active constituent curcumin acts as an orchestrator of whole body inflammatory response, influencing pro-inflammatory enzymes, their transcription factors and gene expression. However, turmeric’s absorption is poor. Meriva, a patented phytosome delivery form of curcumin, binds turmeric’s curcuminoids to phosphatidylcholine to enhance oral absorption and bioavailability by up to 29X. The improved oral bioavailability of curcumin as Meriva® has been translated into clinical efficacy at dosages significantly lower than those associated with uncomplexed curcumin.
Boswellin™, a patented extract of Boswellia serrata, is a mainstay of Chinese and Ayurvedic wellness traditions found to stabilize mast cells, inhibit synthesis and modify release of proinflammatory mediators. Boswellia serrata also appears to work as a non-redox inhibitor of 5-lipoxygenase enzymes.
Rosemary Extract’s key component, rosmarinic acid, influences the production of certain molecules known to support a healthy inflammatory response. The antioxidant properties of rosemary can help support cellular damage caused by free radicals that are released during the inflammatory process.
Ashwagandha (Withania Somnifera), an important plant used in traditional Indian practices, supports a healthy inflammatory response believed to be due to its alkaloid and withanolide contents.
Barberry Root appears to modulate inflammation via its alkaloid constituent, berberine. Preliminary research suggests that berberine blocks production of the pro-inflammatory cytokines interleukin-1 (IL1)-beta and tumor necrosis factor (TNF)-alpha by
blocking nuclear factor-kappaB, the transcription factor responsible for regulation of cytokine production.
Black Cumin Oil: Low concentrations of the constituent nigellone have been shown to inhibit the release of histamine from mast cells in animals. Black cumin seed is thought to have immune-supportive effects. Evidence suggests it may enhance the production of certain human interleukins and alter macrophages.
Bromelain promotes a healthy inflammatory response in part by inhibiting the generation of bradykinin at the inflammatory site via depletion of the plasma kallikrein system, as well as limiting the formation of fibrin by reduction of clotting cascade intermediates. Research suggests that bromelain reduces leukocyte migration into inflamed areas.
Holy basil extract (Ocimum sanctum) seems to have both central and peripheral soothing activity. Constituents of the leaves and stems of holy basil appear to inhibit the pathway of arachidonic acid metabolism.
Polygonum cuspidatum extract: An active component from the roots of Polygonum cuspidatum has been shown to support a healthy inflammatory response. Research indicates that emodin is a potent inhibitor of NF-kappa B activation and expression of adhesion molecules.
Scullcap herb root has a particularly high flavonoid content (over 35%) giving it a yellow color, hence its traditional name of golden root. These flavonoids selectively inhibit enzymes in the arachidonic acid cascade as well as possess antioxidant properties.
Capsimax® is a proprietary matrix that supplies chili pepper-sourced capsaicinoids without gastrointestinal side effects. Capsaicinoids bind to the nerve receptor TRPV1 to promote soothing whole-body comfort.
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