OsteoOne™

Gluten Free
Non-GMO

Bone support formula, with nutrients that promote optimal calcium absorption and retention

Comprehensive formula supports peak bone health and bone density
Optimizes skeletal strength
Supplies building blocks for bone remineralization

Unique Properties

Patient One OsteoOne™ with Ca, D3, K2 Complex supplies comprehensive support for bone health and maintenance. Bone health is dependent on a constant supply of micronutrients and OsteoOne is designed to mimic the composition of healthy bone matrix. By mirroring naturally occurring bone components in carefully calibrated ratios, OsteoOne optimizes the restoration of peak bone mineral density. OsteoOne is formulated with today’s most advanced patented bone health ingredients, which share enhancements for promoting absorption and bioavailability, while supporting digestive comfort for better patient compliance.

Key Ingredients

Calcium and Magnesium:

Over 75% of men and 22% of women fail to get enough calcium. OsteoOne supplies calcium with magnesium, providing essential elements for bone maintenance. OsteoOne’s calcium is presented as DimaCal^® dicalcium malate, a vegan form that is bonded to malic acid to maximize bioavailability. Calcium malate and calcium citrate/malate are both highly bioavailable forms of calcium. In a two-year, double blind, placebo-controlled trial, calcium citrate/malate provided bone mass support for postmenopausal women with low dietary calcium intake. Magnesium supports healthy bone mineralization, and OsteoOne supplies magnesium to further optimize absorption and utilization of DimaCal calcium.

Vitamin D3:

Cholecalciferol (vitamin D3) supports bone health by working with magnesium to aid in the metabolism of calcium, which benefits bone mineral density. Research indicates that those with low vitamin D levels have lower bone mass. Vitamin D also reduces urinary calcium loss. The body’s production of vitamin D declines during aging, making supplementation important for seniors. Cholecalciferol is the form of vitamin D that is naturally occurring, synthesized in skin during exposure to sunlight. However, many factors can limit this production including lack of sun exposure, smog, sunblock, skin melanin content and geographic location.

Vitamin K2 (as VitaMK7™ menaquinone-7):

An ultra-pure form of vitamin K2, VitaMK7 exhibits the highest bioavailability and longest half-life in the blood. Vitamin K2 (menaquinone-7) plays an active role in bone metabolism, calcium utilization and is associated with the reinforcement of bone mineral density. Proteins such as osteocalcin and matrix GLA protein (MPG) that are linked to healthy bone formation are activated by vitamin K2. OsteoOne includes Vitamin K2 for bone mass maintenance. K2 deficiency has been specifically linked to low bone mass in mature women.

Mineral Complex:

OsteoOne is completed with bone-promoting minerals including zinc and manganese as TRAACS^®glycinate chelates and FruiteX-B™ PhytoBoron, as well as natural silica derived from bamboo stems. Zinc and manganese encourage healthy bone density, while boron maintains the wellness of bones and joints. Boron plays an important role in reducing urinary calcium and magnesium excretion. Silica promotes collagen synthesis, aiding in the strength and pliability of bones along with other crucial connective tissue.

Research

In a meta-analysis of 12 clinical trials totaling over 42,000 adults age 65 and up, researchers found that vitamin D supplementation (at a daily level of 400 international units and above) reduced hip fractures by 18% and reduced non-vertebral fractures by 20%.
A population-based, cross-sectional study with more than 2,800 participants found that the intake of dietary silica was notably linked to increased bone mineral density in men and premenopausal women.
A three-year study utilizing 180 ?g/d of MK-7 concluded that MK-7 significantly improved vitamin K status, supported bone mineral content and BMD, and favorably supported bone strength and integrity in healthy postmenopausal women.

References

Ryder KM, et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc. 2005 Nov;53(11):1875-80.
Ikeda Y, et al. Intake of Fermented Soybeans, Natto, Is Associated with Reduced Bone Loss in Postmenopausal Women: Japanese Population- Based Osteoporosis (JPOS) Study. J. Nutr. May 2006 vol. 136 no. 5 1323-1328.
Jugdaohsingh R, et al. Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort. J Bone Miner Res. 2004 Feb;19(2):297- 307. Epub 2003 Dec 16.
Saltman PD, Strause LG. The role of trace minerals in osteoporosis. J Am Coll Nutr. 1993 Aug;12(4):384-9.
Nielsen, F.H., Poellot, R.A. 2004. Dietary silicon affects bone turnover differently in ovariectomized and sham-operated growing rats. Journal of Trace Elements in Experimental Medicine. 17:137-149.
Bischoff-Ferrari et al. Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency: A Meta-analysis of Randomized Controlled Trials. Archives of Internal Medicine, 2009; 169 (6): 551 DOI: 10.1001/archinternmed.2008.600
Shearer MJ. The roles of vitamins D and K in bone health and osteoporosis prevention. Proc Nutr Soc. 1997 Nov;56(3):915-37. [PMID: 9483660]
Knapen MH, Drummen NE, Smit E, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013 Mar 23. [Epub ahead of print] [PMID: 23525894]
Michal Karpinski, Janusz Popko, Katarzyna Maresz, Vladimir Badmaev & Sidney J. Stohs (2017) Roles of Vitamins D and K, Nutrition, and Lifestyle in Low-Energy Bone Fractures in Children and Young Adults, Journal of the American College of Nutrition, 36:5,399-412, DOI: 10.1080/07315724.2017.1307791

Supplement Facts

Serving Size: 4 Tablets
Servings Per Container: 30
Amount Per Serving	% Daily Value**
Vitamin D3 (as cholecalciferol)	25	mcg	125%
Calcium (as DimaCal® Dicalcium Malate, dicalcium phosphate, calcium citrate)	1120	mg	86%
Phosphorus (as dicalcium phosphate)	90	mg	7%
Magnesium (as magnesium oxide)	500	mg	119%
Zinc (as TRAACS® Zinc Glycinate Chelate)	5	mg	45%
Manganese (as TRAACS® Manganese Glycinate Chelate)	2	mg	87%

Vitamin K2 (as VitaMK7® Menaquinone-7)	200	mcg	†
Boron (from 112 mg of FruiteX-B™ PhytoBoron)	3	mg	†
Silica [from Bamboo extract (Bambusa vulgaris) (stems)]	5	mg	†

† Daily Value not established.
** Daily Values are based on a 2,000 calorie per day diet.
Other Ingredients: Microcrystalline cellulose, stearic acid (vegetable), croscarmellose sodium, leucine, aqueous film coating (purified water, hydroxypropyl methylcellulose, glycerin)
This product is free of milk, egg, fish, peanuts, crustacean shellfish, soy, tree nuts, wheat, yeast and gluten. This product is free of ingredients derived from genetically modified organisms (GMOs).
Trademarks: FruiteX-B is a trademark of FutureCeuticals, U.S. Patent #5,962,049. DimaCal® and TRAACS® are registered trademarks of Albion Laboratories, Inc. VitaMK7® is a trademark of Gnosis S.p.A. distributed by AHD International, LLC.

Suggested Use

Take 4 tablets in divided doses, preferably with meals, as a dietary supplement or as directed by your health practitioner. Store in a cool, dry place.

Warnings

If you are pregnant, nursing, have a history of kidney stones, or taking any medications, consult your health practitioner before use. Discontinue use and consult your health practitioner if any adverse reactions occur. Use with caution if you take blood thinners. Calcium should be taken separately from certain antibiotics and thyroid medications. Keep out of reach of children. Use only if safety seal is intact.