Q-Folate (as 5-MTHF Quatrefolic®)

Q-Folate (as 5-MTHF Quatrefolic®)
  • Gluten Free
  • Vegetarian
  • Non-GMO
  • Vegetable Caps

Advanced methyltetrahydrofolic acid form of folate for enhanced bioavailability*

  • Supports mental clarity, memory, and focus*
  • Optimizes new cell growth, health and development*
  • Promotes red blood cell production and DNA genesis*
  • Maintains normal homocysteine levels for cardio health*
  • Provides recommended dose for pregnant or lactating women

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Unique Properties

Patient One’s Q-Folate supplies 800mcg of Quatrefolic®, the glucosamine salt of (6S)-5- methyltetrahydrofolate (5-MTHF), proven to have greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF and over supplementation with folic acid. Folic acid must be converted to its active form, 5-MTHF, which takes four separate biochemical reactions in the intestines and liver, in order for the body to absorb and use it. 

Approximately 60 percent of the U.S. population may have a genetic enzyme defect that makes it difficult for them to convert folic acid into active 5-MTHF, making this biologically active form of folate the preferred form of folate. 5-MTHF is best known for its ability to bypass metabolic steps in order to replenish plasma folate levels in individuals with conditions that can limit conversion or absorption of folic acid.




  1. Venn BJ, et al. Am J Clin Nutr. 2003; 77:658-62.
  2. Passeri M, et al. Aging (Milano) 1993; 5(1):63-71.
  3. Wright AJ, et al. J Nutr. 2010; 103(5):724-9.
  4. Kelly P, et al. Am J Clin Nutr. 1997; 65:1790-5.
  5. Morita H, et al. Circulation 1997; 95:2032-2036.
  6. Ismaili, S. Final Report IPAS-5MTHFA-583-09.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving % Daily Value**

Folate [as Quatrefolic (6S)-5-Methyltetrahydrofolic acid equivalent to 1600 mcg (6S)-5-Methyltetrahydrofolic acid, glucosamine salt]

1333 mcg DFE 333%
** Daily Values are based on a 2,000 calorie per day diet.

Suggested Use

Take 1 capsule with a meal as a dietary supplement or as directed by your health practitioner. Store in a cool, dry place.


Consult your health practitioner before use if you are pregnant, nursing, or taking any medications. Discontinue use and consult your health practitioner if any adverse reactions occur. Keep out of reach of children. Use only if safety seal is intact.

Q-Folate (as 5-MTHF Quatrefolic®) Label