• Gluten Free
  • Vegetarian
  • Non-GMO
  • Vegetable Caps

Nutritional support for healthy mood, sleep and stress*

  • Promotes increased serotonin levels*
  • Supports normal sleep patterns*
  • Enhances positive mood*
  • Aids with managing occasional stress*
  • Helps regulate appetite and sugar cravings*

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Unique Properties

5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid tryptophan. Tryptophan is converted into 5-HTP, which in turn is converted into serotonin, an important neurotransmitter that is associated with the regulation of sleep, mood, appetite, temperature and more. 

Supplementation with 5-HTP is preferable to supplementing with L-tryptophan. 5-HTP is derived naturally from the seeds of the Griffonia plant, where L-tryptophan is produced synthetically or through bacterial fermentation. 5-HTP crosses into the brain more readily than L-tryptophan, as it is able to cross the blood-brain barrier without competing with other amino acids for uptake. Unlike L-tryptophan, 5-HTP cannot be shunted into niacin or protein production. 

Supplementing with 5-HTP provides the advantage of bypassing the conversion of L-tryptophan into 5-HTP, eliminating possible obstacles in the synthesis of serotonin. This conversion process can be inhibited by many factors including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron. 

Oral 5-HTP is well-absorbed in the intestine without the need for a transporter and is not affected by the presence of other amino acids. As such, it may be taken with meals. 



  1. Cangiano C, et al. Am J Clin Nutr. 1992; 56:863-67.
  2. Cangiano C, et al. Int J Obes Relat Metab Disord. 1998; 22(7):648-54.
  3. Ribeiro CA. Headache. 2000; 40(6):451-56.
  4. Nagata E, et al. Headache. 2006; 46(4):592-96.
  5. Byerley WF, et al. J Clin Psychopharmacol. 1987; 7:127-137.
  6. Poldinger W, et al. Psychopathology. 1991; 24:53-81.
  7. Kahn RS, et al. Int Clin Psychopharmacol. 1987; 2:33-45.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving % Daily Value**

(Gryffonia simplicifolia) (seed)

100 mg
† Daily Value not established.

Suggested Use

Take 1 capsule 1 to 2 times daily in divided doses between meals, as a dietary supplement or as directed by your health practitioner. To derive optimal benefits of 5-HTP, ensure adequate intake of Vitamin B6. Store in a cool, dry place.


Consult your health practitioner before use. Do not use concurrently with SSRI medications, MAO inhibitors or other antidepressant medication. Not recommended if pregnant or nursing or for children under age 12. Discontinue use and consult your health practitioner if any adverse reactions occur. Keep out of reach of children.

5-HTP Label