Milk Thistle Extract 250 mg

Milk Thistle Extract 250 mg
  • Gluten Free
  • Non-GMO
  • Vegetarian
  • Vegetable Caps

Natural support for healthy liver function

  • Supports the body's natural elimination of toxins
  • Enhances healthy hepatic function
  • Provides liver-protective support

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Product Information Sheet (PDF)

Patient One Milk Thistle vegetarian capsules supply 250 mg of milk thistle extract, standardized to contain a minimum of 80% of the flavonoid silymarin.

A common herb native to the Mediterranean, milk thistle has been broadly used for its nutritional support of liver function for two centuries. Seeds of the dried milk thistle flower are rich in silymarin, a bioflavonoid complex of silybin, silydianin, and silychristin. Silymarin is responsible for milk thistle’s powerful protective and regenerative activities in the liver.

The liver is the body’s detoxifying organ, disabling toxins such as ethanol, environmental poisons, pesticides, and certain pharmaceuticals. When damaged or diseased, the liver’s ability to eliminate toxins and perform its numerous other functions may be severely impaired. This highly active botanical has been shown to support and enhance normal, healthy liver function.

Silymarin protects the liver from free radical damage, supports glutathione concentrations and promotes superoxide dismutase activity. Milk thistle extract also stimulates protein synthesis in hepatic cells.

Studies showed that milk thistle improved control of blood sugar in people with diabetes with and without liver disease. Research also suggests that silymarin improves blood and urine markers associated with diabetic kidney disease. In unhealthy liver conditions caused by viruses or alcohol, several studies reported improvements in liver tests with use of milk thistle. A number of studies in Europe suggest benefits of oral milk thistle for cirrhosis. 



  • Scientific studies show that oral supplementation with silymarin can help support liver function. (8-13)
  • Silymarin has been shown to combat lipid peroxidation, wherein excess liver fat turns rancid under continuous assault from free radicals. (12-15)
  • Research has also demonstrated that silymarin may help promote healthy liver cells. (9)


  1. Flora, K, Hahn, M, Rosen, H, Benner, K. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 1998;93:139-43.
  2. Bass, NM. Is there any use for nontraditional or alternative therapies in patients with chronic liver disease? Curr Gastroenterol Rep 1999;1:50-6.
  3. Par, A, Roth, E, Rumi, G, Jr., Kovacs, Z, Nemes, J, Mozsik, G. [Oxidative stress and antioxidant defense in alcoholic liver disease and chronic hepatitis C]. Orv Hetil 2000;141:1655-9.
  4. Edwards, J, Grange, LL, Wang, M, Reyes, E. Fetoprotectivity of the flavanolignan compound siliphos against ethanol- induced toxicity. Phytother Res 2000;14:517-21.
  5. Berkson, BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Med Klin 1999;94 Suppl 3:84-9.
  6. Farghali, H, Kamenikova, L, Hynie, S, Kmonickova, E. Silymarin effects on intracellular calcuim and cytotoxicity: a study in perfused rat hepatocytes after oxidative stress injury. Pharmacol Res 2000;41:231-7.
  7. Kropacova, K, Misurova, E, Hakova, H. Protective and therapeutic effect of silymarin on the development of latent liver damage. Radiate Biol Radioecol 1998;38:411-5.
  8. Bratisl Lek Listy. 2012;113(3):145-51.
  9. J Vet Intern Med. 2012 Nov 9. doi: 10.1111/jvim.12002.
  10. J Oncol Pharm Pract. 2012 Sep;18(3):360-5.
  11. Phytomedicine. 2009 May;16(5):391-400.
  12. Int J Clin Pharmacol Ther. 2002 Jan;40(1):2-8.
  13. J Hepatol. 1997 Apr;26(4):871-9.
  14. J Agric Food Chem. 2008 Jun 11;56(11):3966-72.
  15. Arzneimittelforschung. 1998 Mar;48(3):236-9.
  16. Deep, Gagan, Subhash Chander Ganger, and Subapriya Rajamanickam, et al. "Amgiopreventive Efficacy of Pure Flavonolignans from Milk Thistle Extract against Prostate Cancer: Targeting VEGF-VEGFR Signalin." Plos One, 2012 Apr. 2012.
  17. Li, Sha, Hor Yue Tan, Ning Wang, Zhang Jin Zhang, Li Xing Lao, Chi Woon Wong, and Yi Bin Feng. "The Role of Oxidative Stress and Antioxidants in Liver Diseases." MDPI. International Journal of Molecular Sciences, 2 Nov. 2015.
  18. Dixit, Nitin, Sanjula Baboota, Kanchan Kohli, S. Ahmad, and Javed Ali. "Silymarin: A Review of Pharmacological Aspects of Bioavailability Enhancement Approaches." Indian J Pharmacol. Indian J Pharmacol, Aug. 2007.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 90
Amount Per Serving % Daily Value**
Milk Thistle Extract

(Silybum marianum) (seeds) [Standardized to contain a minimum of 80% Silymarin]

250 mg
† Daily Value not established.

Suggested Use

Take 1 capsule up to 4 times daily, in divided doses between meals, or as directed by your health practitioner. Store in a cool, dry place.


Avoid this product if you are allergic to ragweed or daisy-like products. If you are pregnant, nursing, or taking any medications, consult your health practitioner before use. Discontinue use and consult your health practitioner if any adverse reactions occur. Keep out of reach of children. Use only if safety seal is intact.

Milk Thistle Extract 250 mg Label