Patient One endocrine support supplements are designed to support healthy hormone balance by optimizing health and function of the thyroid and hypothalamic-pituitary-adrenal axis. Our formulas’ standardized, high-potency Ayurvedic and adaptogenic herbs address the far-reaching effects of hormonal imbalance -- helping to promote energy, stress resistance, healthy mood, mental clarity and more.
Alpha Lipoic Acid (ALA) is a fat- and water-soluble nutrient with antioxidant activity. A sulfur-containing compound present in human cells, it is required for energy production within the mitochondria and provides protection both inside and outside the cell. ALA has the ability to regenerate and extend the biochemical lifetime of other antioxidants, such as vitamins C and E, as well as glutathione and coenzyme Q10 (CoQ10). As such, it plays a role in fighting oxidative stress and free radical formation. As a coenzyme, ALA is needed to break down glucose for energy metabolism.
This versatile nutrient has been shown to support vascular and connective tissue health, protect cell structures, support the nervous system, help maintain healthy liver function and help maintain cholesterol and blood glucose levels within normal ranges. Because of its antioxidant properties and its ability to improve blood vessel circulation to the nerves, ALA has been studied for its ability to improve circulation, particularly in the nervous system.
Alpha lipoic acid can be made in the body but production declines with age. ALA supports healthy aging, reducing oxidative stress in the brain, eyes and heart. ALA helps neutralize free radicals before they can cause damage to the elastin and collagen in the skin that can be linked to signs of aging and wrinkles. ALA also provides support for althletes by producing energy in muscles and directing calories into energy production.
Research
More than a dozen clinical trials have studied the role of alpha lipoid acid in maintaining healthy nerve function. Findings demonstrate its neuroprotective function, believed to be due to ALA's ability to modulate nitric oxide metabolite activity and to promote healthy microcirculation.
References
Evans JL, Goldfine ID: a-Lipoic acid: a multi-functional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Therap 2:401-413, 2000
Li Y, Liu YZ, Shi JM, et al. Alpha lipoic acid protects lens from H(2)O(2)-induced cataract by inhibiting apoptosis of lens epithelial cells and inducing activation of anti-oxidative enzymes. Asian Pac J Trop Med. 2013 Jul;6(7):548-51. [PMID: 23768827]
Pershadsingh HA. Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome. Expert Opin Investig Drugs. 2007 Mar;16(3):291-302 [PMID: 17302524]
Foster TS. Efficacy and safety of {alpha}-lipoic acid supplementation in the treatment of symptomatic diabetic neuropathy. Diabetes Educ. 2007 Jan- Feb;33(1):111-7 [PMID: 17272797]
Singh VP, Bali A, Singh N, et al. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol. 2014 Feb;18(1):1-14. Epub 2014 Feb 13. [PMID: 24634591]
Teichert J, Kern J, Tritschler HJ, Ulrich H, Preiss R: Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. Int.J.Clin. Pharmacol.Ther. 36:625-628, 1998
Winkler BS, Boulton ME, Gottsch JD, et al. Oxidative damage and age-related macular degeneration. Mol Vis. 1999 Nov 3;5:32. [PMID: 10562656]
Xiang GD, Sun HL, Zhao LS, Hou J, Yue L, Xu L. The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycemia during OGTT in impaired glucose tolerance. Clin Endocrinol (Oxf) (2008)68(5):716-23.
Packer L, Cadenas E. Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. J Clin Biochem Nutr (2011) 48(1):26-32.
Wang Y, Li X, Guo Y, Chan L, Guan X. Alpha-Lipoc acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor gamma coactivator-1alpha signaling in the skeletal muscle of aged mice. Metabolism (2010)59(7):967-76.
Saliminen A, Jyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-kB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl)(2011) 89(7):667-76.
Lee, Jung Eun, and Chin-ok Yi, et al. "Alpha-lipoc Acid Attenuates Cardiac Fibrosis in Otsuka Long-Evans Toskushima Fatty Rats." Cardio Vascular Diabetology. Cardio Vascular Diabetology, n.d.
Chun, Jun Li, Lv Lin, and Yu De Min. "Cardiac Fibrosis and Dysfunction in Experimental Diabetic Cardiomyopathy Are Ameliorated by Alpha- Lipoid Acid." Cardio Vascular Diabetology. Cardio Vascular Diabetology, n.d.
Made with ingredients that are free of milk, egg, fish, peanuts, crustacean shellfish, soy, tree nuts, wheat, yeast, gluten, sesame and GMOs.
Suggested Use
Take 1 capsule twice daily, preferably with meals, or as directed by your health practitioner. May take up to 1800 mg daily in divided doses. Store in a cool, dry place.
Warnings
If you are pregnant, nursing, or taking any medications, consult your health practitioner before use. Discontinue use and consult your health practitioner if any adverse reactions occur. Keep out of reach of children. Use only if safety seal is intact.
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