5-HTP with Vitamin B6

5-HTP with Vitamin B6
  • Gluten Free
  • Vegetarian
  • Non-GMO
  • Vegetable Caps

Nutritional support for healthy mood, sleep and stress*

  • Increases serotonin levels*
  • Supports normal sleep patterns*
  • Enhances positive mood*
  • Aids with managing occasional stress*
  • Helps regulate appetite and sugar cravings*
  • Includes co-factor Vitamin B6 as P-5-P*

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Unique Properties

5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid tryptophan. Tryptophan is converted into 5-HTP, which in turn is converted into serotonin, an important neurotransmitter that is associated with the regulation of sleep, mood, appetite, temperature and more. 

Supplementation with 5-HTP is preferable to supplementing with its precursor, L-tryptophan. 5-HTP is derived naturally from the seeds of the Griffonia plant, where L-tryptophan is produced synthetically or through bacterial fermentation. 5-HTP readily crosses into the brain and in the presence of co-factor pyridoxal phosphate, derived from Vitamin B6 which is included in this formula, can be synthesized into serotonin.

Supplementing with 5-HTP provides the advantage of bypassing the conversion of L-tryptophan into 5-HTP, eliminating possible obstacles in the synthesis of serotonin. This conversion process can be inhibited by many factors including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron. 

Oral 5-HTP is well-absorbed in the intestine without the need for a transporter and is not affected by the presence of other amino acids. As such, it may be taken with meals. 


  1. Cangiano C, et al. Am J Clin Nutr. 1992; 56:863-67.
  2. Cangiano C, et al. Int J Obes Relat Metab Disord. 1998; 22(7):648-54.
  3. Ribeiro CA. Headache. 2000; 40(6):451-56.
  4. Nagata E, et al. Headache. 2006; 46(4):592-96.
  5. Byerley WF, et al. J Clin Psychopharmacol. 1987; 7:127-137.
  6. Poldinger W, et al. Psychopathology. 1991; 24:53-81.
  7. Kahn RS, et al. Int Clin Psychopharmacol. 1987; 2:33-45.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving % Daily Value**

Vitamin B-6 (as pyridoxal-5-phosphate)

20 mg 1176%

(Gryffonia simplicifolia) (seed)

100 mg
† Daily Value not established.
** Daily Values are based on a 2,000 calorie per day diet.

Suggested Use

Take 1 capsules preferably on an empty stomach at bedtime, as a dietary supplement or as directed by your health practitioner. Store in a cool, dry place.


Consult your health practitioner before use. Do not use concurrently with SSRI medications, MAO inhibitors or other antidepressant medication. Not recommended if pregnant or nursing. Discontinue use and consult your health practitioner if any adverse reactions occur. Keep out of reach of children.

5-HTP with Vitamin B6 Label