Olive Leaf Extract 500 mg

Olive Leaf Extract 500 mg
  • Gluten Free
  • Non-GMO
  • Vegetarian
  • Vegetable Caps

Promotes a healthy intestinal environment, supports heart health and provides immune support

  • Provides GI microbial defense
  • Promotes cardiovascular health
  • Supports healthy BP levels already in normal range
  • Promotes healthy blood sugar levels
  • Provides antioxidant and anti-inflammatory properties

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Product Information Sheet (PDF)

For thousands of years, olive leaves and their extracts have been consumed in the Mediterranean diet for diverse health benefits and overall well-being. Olive tree leaves produce eutrophic compounds as a defense mechanism against environmental stressors including bacteria, fungi, parasites and insects. These anti-microbial compounds have been shown to naturally protect and support a healthy cellular environment, without adversely impacting immune function or beneficial microflora. As a natural substance that exhibits antibacterial, antiviral and antifungal activity, olive leaf supports peak immune health.

Olive leaves contain high amounts of oleuropein, the active nutrient responsible for its wide range of beneficial effects. Patient One's Olive Leaf formula supplies 500 mg of olive leaf extract that is highly standardized, to provide a minimum of 20% oleuropein. The olive leaf also contains the bioflavonoids rutin, luteolin, and hesperidin that further enhance the activity of oleuropein.

Olive leaf has been studied for its effect in supporting healthy lipid and blood pressure levels. Equally important for heart health, olive leaf promotes healthy arterial and endothelial function, helping to relax blood vessels and avoid formation of arterial plaques.

Human and animal studies have shown that supplementation with olive leaf extract reduced blood glucose levels through several mechanisms. Olive leaf slows the digestion of starches into simple sugars, slows absorption of those sugars from the intestine, and increases the uptake of glucose into tissues from the blood.

Further, olive leaf has been shown to provide protection against oxidative damage and promote healthy inflammatory response.


  • Human studies reveal that supplementing with 500 mg of olive leaf extract once daily resulted in significant reductions in hemoglobin A1c levels, the standard marker of long-term exposure to elevated blood sugar in diabetic people. Supplementation also lowered fasting plasma insulin levels.
  • Research has demonstrated that olive leaf extracts help prevent the oxidation of LDL-cholesterol, a frequent precursor in developing atherosclerosis. They also support increased production of nitric oxide, a signaling molecule that helps relax blood vessels.


  1. Poudyal H, Campbell F, Brown L. Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats. J Nutr. 2010 May;140(5):946-53.
  2. Kontou N, Psaltopoulou T, Soupos N, et al. Metabolic syndrome and colorectal cancer: the protective role of Mediterranean diet--a case-control study. Angiology. 2012 Jul;63(5):390-6.
  3. Verberne L, Bach-Faig A, Buckland G, Serra-Majem L. Association between the Mediterranean diet and cancer risk: a review of observational studies. Nutr Cancer. 2010;62(7):860-70.
  4. Fares R, Bazzi S, Baydoun SE, Abdel-Massih RM. The antioxidant and anti-proliferative activity of the Lebanese Olea europaea extract. Plant Foods Hum Nutr. 2011 Mar;66(1):58-63.
  5. Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm. 2010;78(2):133-54.
  6. Mohagheghi F, Bigdeli MR, Rasoulian B, Hashemi P, Pour MR. The neuroprotective effect of olive leaf extract is related to improved blood-brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia. Phytomedicine. 2011 Jan 15;18(2-3):170-5.
  7. Wahle KW, Caruso D, Ochoa JJ, Quiles JL. Olive oil and modulation of cell signaling in disease prevention. Lipids.2004 Dec;39(12):1223-31.
  8. Waterman E, Lockwood B. Active components and clinical applications of olive oil. Altern Med Rev. 2007 Dec;12(4):331-42.
  9. Somova LI, Shode FO, Ramnanan P, Nadar A. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. J Ethnopharmacol.2003 Feb;84(2-3):299-305.
  10. Visioli F, Bellosta S, Galli C. Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages. Life Sci. 1998;62(6):541-6.
  11. Rocha BS, Gago B, Barbosa RM, Laranjinha J. Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology.2009 Nov 9;265(1-2):41-8.
  12. Palmieri D, Aliakbarian B, Casazza AA, et al. Effects of polyphenol extract from olive pomace on anoxia-induced endothelial dysfunction. Microvasc Res. 2012 May;83(3):281-9.
  13. Scoditti E, Calabriso N, Massaro M, et al. Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch Biochem Biophys. 2012 Nov 15;527(2):81-9.
  14. Jemai H, Bouaziz M, Fki I, El Feki A, Sayadi S. Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves. Chem Biol Interact. 2008 Nov 25;176(2-3):88-98.
  15. Masella R, Vari R, D’Archivio M, et al. Extra virgin olive oil biophenols inhibit cell-mediated oxidation of LDL by increasing the mRNA transcription of glutathione-related enzymes. J Nutr.2004 Apr;134(4):785-91.
  16. Wang L, Geng C, Jiang L, et al. The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis. Eur J Nutr. 2008 Aug;47(5):235-43.
  17. Dell’Agli M, Fagnani R, Mitro N, et al. Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation. J Agric Food Chem. 2006 May 3;54(9):3259-64.
  18. Singh I, Mok M, Christensen AM, Turner AH, Hawley JA. The effects of polyphenols in olive leaves on platelet function. Nutr Metab Cardiovasc Dis. 2008 Feb;18(2):127-32.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 90
Amount Per Serving % Daily Value**
Olive Leaf extract (Oleo europaea L.) (leaves)

[Standardized for minimum 20% oleuropein (100mg)]

500 mg
† Daily Value not established.

Suggested Use

Take 1 capsule 1-2 times daily, in divided doses with meals, or as directed by your health practitioner. Store in a cool, dry place.


Pregnant or lactating women and those taking blood pressure or other medications, consult health practitioner before use. Discontinue use and consult health practitioner if any adverse reactions occur. Keep out of reach of children. Use only if safety seal is intact.

Olive Leaf Extract 500 mg Label