Saffro-Calm Plus

Saffro-Calm Plus
  • Gluten Free
  • Vegetarian
  • Non-GMO

Herbal-based oral spray for natural stress and mood support*

  • Promotes emotional wellness and a positive outlook*
  • Provides support for occasional stress and uneasiness*
  • Promotes sense of relaxation without drowsiness*
  • Enhances ability to sleep*

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Patient One Saffro-Calm Plus oral spray is formulated with a unique and synergistic combination of botanicals to calm feelings of occasional stress without drowsiness. Because the botanicals in Saffro-Calm Plus have been shown to interact with the body's endocannabinoid system (ECS), this formula is part of our ECS Synergy™ series. 

Our pleasant tasting spray is for oral use, to be taken by mouth, and may be used by adults and adolescents. Saffro-Calm Plus is convenient to carry when on the go or to easily access on a bedside table. For best results use Saffro-Calm Plus consistently, morning and evening. 


  1. Almodóvar P, et al. Evidence-Based Complementary and Alternative Medicine. 2020; 1–8.
  2. Jackson P. A., et al. Frontiers in Nutrition, 2021; 7:606124.
  3. Kell G et al. Therapies in Medicine, 2017; 33:58–64.
  4. Lopresti, A. L. Journal of Affective Disorders, 2015;181:24–32.
  5. Lopresti A. L., et al. 2021; 27(2):66.
  6. Lopresti A. L., et al. Journal of Affective Disorders. 2018; 232:349–357.
  7. Lopresti A. L., et al. Sleep Medicine. 2021; 86:7-18.
  8. Lopresti A. L., et al. Journal of Clinical Sleep Medicine. 2020; 16(6):937–947.
  9. Nishide A., et al. Japan Pharmacology and Therapeutics, 46(8):1407–1415.
  10. Woelkart K, et al. Planta Medica, 2007; 73(7):615-623.

Supplement Facts

Serving Size: 4 Sprays (0.66 mL)
Servings Per Container: 45
Amount Per Serving % Daily Value**

Affron®: saffron (Crocus Sativus L.)
stigmas extract [Std. to 3.5% Lepticrosalides®]

28 mg

Echinacea angustifolia extract (root)
[Contains echinacosides and alkamids]

30 mg
† Daily Value not established.

Suggested Use

Adults and adolescents age 12 and up, take 1 serving orally (4 sprays) in divided doses (2 sprays in the morning and 2 sprays in the evening). For best results, use consistently approximately every 12 hours to ensure the body has an effective amount at all times.


Do not take if pregnant or nursing. If taking any medications, consult doctor before use. Discontinue use and consult doctor if any adverse reactions occur. Keep out of reach of children.