Saffro-Calm Plus

Saffro-Calm Plus
  • Gluten Free
  • Non-GMO
  • Vegetarian

Herbal-based oral spray for natural stress and mood support

  • Promotes emotional wellness and a positive outlook
  • Provides support for occasional stress and uneasiness
  • Promotes sense of relaxation without drowsiness
  • Enhances ability to sleep

Login to Order

Product Information Sheet (PDF)

Patient One Saffro-Calm Plus oral spray is formulated with a unique and synergistic combination of botanicals to calm feelings of occasional stress without drowsiness. Because the botanicals in Saffro-Calm Plus have been shown to interact with the body's endocannabinoid system (ECS), this formula is part of our ECS Synergy™ series. 

Our pleasant tasting spray is for oral use, to be taken by mouth, and may be used by adults and adolescents. Saffro-Calm Plus is convenient to carry when on the go or to easily access on a bedside table. For best results use Saffro-Calm Plus consistently, morning and evening, approximately every 12 hours.

Key Ingredients

affron® Saffron

In more than 5 published human clinical studies, affron® Saffron has been shown as effective at a low daily dose of 28 mg to calm occasional irritability and stress, promote mental balance, maintain a healthy mood and to support restful sleep. Made from Spanish saffron (Crocus sativus), affron's patented formulation is standardized to provide 3.5% Lepticrosalides®, a complex of bioactive compounds responsible for its beneficial and organoleptic properties.

Affron's dual mechanisms of action include

  • reuptake inhibition of dopamine, norepinephrine and serotonin, increasing the concentration of these neurotransmitters in the synaptic cleft of neurons, thereby improving mood balance, and  
  • antioxidant effect against the excessive oxidative stress produced during anxiety or stress processes in the central nervous system.

Scientific studies have associated saffron with modulation of the body's endocannabinoid system. 

Echinacea augustifolia 

Saffro-Calm Plus also includes Echinacea augustifolia for added support in reducing occasional tension and promoting a relaxed, positive mood. While this herb is typically associated with immune system support, the root extract in our formula contains alkamides along with echinacosides. It has been found that alkamides bind significantly to and activate the body's cannabinoid (CB2) receptors in the endocannabinoid system. 

Alkamides are bioactive compounds that show structural similarity with anandamide, an endogenous ligand of cannabinoid receptors. Anandamide is a neurotransmitter that binds to cannabinoid receptors in the brain and body, stimulating a sense of happiness and mental balance. Anandamide is a little-known brain chemical that's been called the “bliss molecule” for the role it plays in producing feelings of happiness. 


  1. Almodóvar, P., Briskey, D., Rao, A., Prodanov, M., & Inarejos-García, A. M. (2020). Bioaccessibility and pharmacokinetics of a commercial saffron (Crocus sativus L.) extract. Evidence-Based Complementary and Alternative Medicine, 2020, 1–8.
  2. Jackson, P. A., Forster, J., Khan, J., Pouchieu, C., Dubreuil, S., Gaudout, D., Moras, B., Pourtau, L., Joffre, F., Vaysse, C., Bertrand, K., Abrous, H., Vauzour, D., Brossaud, J., Corcuff, J. B., Capuron, L., & Kennedy, D. O. (2021). Effects of saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults: A randomized, double-blind, Parallel Group, clinical trial. Frontiers in Nutrition, 7.
  3. Kell, G., Rao, A., Beccaria, G., Clayton, P., Inarejos-García, A. M., & Prodanov, M. (2017). AFFRON ® a novel saffron extract ( Crocus Sativus L .) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complementary Therapies in Medicine, 33, 58–64.
  4. Lopresti, A. L. (2015). A review of nutrient treatments for paediatric depression. Journal of Affective Disorders, 181, 24–32.
  5. Lopresti, A. L., & Smith, S. J. (2021). The effects of a saffron extract (affron®) on menopausal symptoms in women during perimenopause: A randomised, double-blind, placebo-controlled study. Journal of Menopausal Medicine, 27(2), 66.
  6. Lopresti, A. L., Drummond, P. D., Inarejos-García, A. M., & Prodanov, M. (2018). AFFRON®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders, 232, 349–357.
  7. Lopresti, A. L., Smith, S. J., & Drummond, P. D. (2021). An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: A randomised, double-blind, placebo-controlled, multi-dose study. Sleep Medicine, 86, 7–18.
  8. Lopresti, A. L., Smith, S. J., Metse, A. P., & Drummond, P. D. (2020). Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: A randomized, double-blind, placebo-controlled trial. Journal of Clinical Sleep Medicine, 16(6), 937–947.
  9. Nishide, A., Fujita, T., Nagaregawa, Y., Shoyama, Y., Ohnuki, K., Shimizu, K., Yamamoto, T., Watanabe, T., & Ohnuki, K. (n.d.). Sleep Enhancement by Saffron Extract affron® in Randomized Control Trial. Japan Pharmacology and Therapeutics, 46(8), 1407–1415.
  10. Woelkart, K., & Bauer, R. (2007). The role of Alkamides as an active principle of echinacea. Planta Medica, 73(7), 615–623.

Supplement Facts

Serving Size: 4 Sprays (0.66 mL)
Servings Per Container: 45
Amount Per Serving % Daily Value**

Affron®: saffron (Crocus Sativus L.)
stigmas extract [Std. to 3.5% Lepticrosalides®]

28 mg

Echinacea angustifolia extract (root)
[Contains echinacosides and alkamids]

30 mg
† Daily Value not established.

Suggested Use

Adults and adolescents age 12 and up, take 1 serving orally (4 sprays) in divided doses (2 sprays in the morning and 2 sprays in the evening). For best results, use consistently approximately every 12 hours to ensure the body has an effective amount at all times.


Do not take if pregnant or nursing. If taking any medications, consult doctor before use. Discontinue use and consult doctor if any adverse reactions occur. Keep out of reach of children.