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Enflamen™

Enflamen™
gluten free vegetable capsule Non GMO Supplement

Natural inflammation-modulating blend of standardized botanical extracts, potent antioxidants and Omega-3 fatty acids

  • Modulates inflammation throughout the body
  • Promotes soothing comfort in joints and connective tissues
  • Optimizes flexibility, range of motion and mobility
  • Natural formula, gentle on the stomach

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Product Information Sheet (PDF)

Unique Properties

Patient One Enflamen™ mediates activity of proinflammatory prostaglandins and enzymes with a broad range of standardized botanical extracts, antioxidants and omega-3 fish oil. Enflamen’s comprehensive nutritional support modulates inflammation throughout the body while promoting targeted, soothing comfort in the joints and connective tissue. Additionally, Enflamen supports effective functioning of macrophage immune cells and enhances the body’s natural defense system. 

Key Ingredients

Omega-3 Fish Oils:

Omega-3 polyunsaturated fatty acids (PUFA) from fish oil possess potent immunomodulatory activities, especially the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in Enflamen. EPA and DHA influence production of beneficial eicosanoids that modulate inflammatory responses but are also believed to act upon gene expression and intracellular signaling pathways to promote normal immune responses.

Meriva® Turmeric Phytosome™ 

Turmeric’s active constituent curcumin acts as an orchestrator of whole body inflammatory responses, influencing pro-inflammatory COX enzymes, their transcription factors and gene expression. However, turmeric’s absorption is poor. Meriva, a patented Phytosome delivery form of curcumin, binds turmeric’s curcuminoids to phosphatidylcholine to enhance oral absorption and bioavailability by up to 29X. The improved oral bioavailability of curcumin as Meriva® has been translated into clinical efficacy for addressing the natural inflammatory response function at dosages significantly lower than those associated to uncomplexed curcumin.

Boswellin™:

This patented extract of Boswellia serrata, a resin mainstay of Traditional Chinese and Ayurvedic wellness traditions, has been found to stabilize mast cells, inhibit synthesis and modify release of proinflammatory mediators. Boswellia serrata also appears to work as a non-redox inhibitor of 5-lipoxygenase enzymes.

Rosemary extract:

A key component of rosemary, rosmarinic acid, increases the production of anti-inflammatory signaling molecules while reducing the production of pro-inflammatory leukotrienes. It also inhibits a key step of the complement system, an alternate pathway of inflammation. In addition, the antioxidant properties of rosemary extract can help reduce cellular damage caused by free radicals that are released during the inflammatory process.

Ginger:

Used since antiquity, Zingiber officinale contains phytochemicals and has demonstrated therapeutic benefits for joint and muscle discomfort. The anti-inflammatory effect of ginger has been scientifically proven by its potential inhibitory effect in reducing prostaglandin synthesis and leukotriene biosynthesis.

Ashwagandha extract:

An important medicinal plant used in traditional Indian medicine, Withania somnifera’s anti-inflammatory effect is believed to be due to its alkaloid and withanolide contents.

Barberry extract:

European barberry root appears to have anti-inflammatory activity, believed to be mediated by its alkaloid constituent, berberine. Preliminary research suggests that berberine blocks production of the pro-inflammatory cytokines interleukin-1 (IL1)-beta and tumor necrosis factor (TNF)-alpha by blocking nuclear factor-kappaB, the transcription factor responsible for regulation of cytokine production.

Black cumin oil:

Low concentrations of the constituent nigellone have been shown to inhibit the release of histamine from mast cells in animals. Black [cumin] seed is thought to have immune-protectant effects. Preliminary evidence suggests it may enhance the production of certain human interleukins and alter macrophages.

Bromelain:

Bromelain’s anti-inflammatory action is in part a result of inhibiting the generation of bradykinin at the inflammatory site via depletion of the plasma kallikrein system, as well as limiting the formation of fibrin by reduction of clotting cascade intermediates. Research suggests that bromelain reduces leukocyte migration into inflamed areas and prevents firm adhesion of leukocytes to blood vessels at the site of inflammation.

Holy basil extract:

Holy basil (Ocimum sanctum) leaf extract seems to have both central and peripheral analgesic activity. Constituents of the leaves and stems of holy basil appear to inhibit the cyclooxygenase (COX) pathway of arachidonic acid metabolism.

Polygonum cuspidatum extract:

An active component from the roots of Polygonum cuspidatum has been reported to exhibit anti-inflammatory properties. Research indicates that emodin is a potent inhibitor of NF-kappa B activation and expression of adhesion molecules and thus could be useful in treating various inflammatory conditions.

Scullcap herb powder:

Scullcap has been used to treat inflammatory-related disorders in China and Japan for centuries. The plant root has a particularly high flavonoid content (over 35 %) giving it a yellow color, hence its traditional name of golden root. These flavonoids selectively inhibit enzymes in the arachidonic acid cascade as well as possess antioxidant, antiviral, antiretroviral, antibacterial, and sedative properties.  

Capsimax®:

Capsimax is a proprietary matrix that supplies chili pepper-sourced capsaicinoids without gastrointestinal side effects. Capsimax’s capsaicinoids promote soothing whole-body comfort that complements Enflamen’s inflammation-modulating activity.

Research

  • In a double-blind, randomized, placebo-controlled trial, 30 kidney problem patients were given either fish oil (960 mg/d of EPA and 600 mg/d of DHA) or placebo daily for six months. At trial’s end, the fish oil group was found to have a significant reduction in C-reactive protein (CRP) levels as compared to placebo group.
  • In a trial investigating Meriva® efficacy in promoting comfort, researchers found in patients taking Meriva, global WOMAC pain score decreased by 58% and walking distance improved from 76m to 332m. In the control group, WOMAC decreased by 2% and walking improved from 82m to 129m.
  • In a randomized, double-blind, placebo-controlled crossover study, Boswellia serrata extract was found to reduce knee pain and increase knee flexibility.

References

  1. Bowden RG, Wilson RL, Deike E, Gentile M. Fish oil supplementation lowers C-reactive protein levels independent of triglyceride reduction in patients with end-stage renal disease. Nutr Clin Pract. 2009 Aug- Sep;24(4):508-12. Epub 2009 May 21.
  2. Belcaro G., Cesarone M. R., Dugall M. et al., Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis, Panminerva Medica 2010 Giugno;52(2 Suppl 1).55-62.
  3. Ammon, H. P., Safayhi, H., Mack, T., and Sabieraj, J. Mechanism of anti-inflammatory actions of curcumine and boswellic acids. J Ethnopharmacol. 1993;38(2-3):113-119
  4. Kimmatkar, N., Thawani, V., Hingorani, L., and Khiyani, R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized, double-blind placebo-controlled trial. Phytomedicine. 2003;10(1):3-7.
  5. Altinier, G., S., Aquino, R., Mencherini, T., Loggia, R., & Tubaro, A. (2007).
  6. Characterization of Topical Antiinflammatory Compounds in Rosmarinus officinalis L. Journal of Agriculture & Food Chemistry, 1718-1723.
  7. Badreldin, Ali H.. Blunden, Gerald. Tanira, Musbah O.. Nemmar, Abderrahim. (2008). Some phytochemical, pharmacological and toxicological properties of ginger (zingiber officinale roscoe): a review of recent research. Food and Chemical Toxicology . , 46(), 409-420.
  8. Chandrasekhar, K.. Kapoor, Jyoti. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root . Indian Journal of Medicine . , 34(3), 255-262.
  9. Choudhury, Sudhansa s.. Bashyam, Leena. Manthapuram, Nalini. Bitla, Prasanth. (2014). Ocimum sanctum leaf extracts attenuate human monocytic (thp-1) cell activation. Journal of Ethnopharmacology. , 154(), 148-155.
  10. Lee, Chih-chen. Chen, Yen-Ting. Chiu, Chien-Chih. (2015). Polygonum cuspidatum extracts as bioactive antioxidaion, anti-tyrosinase, immune stimulation and anticancer agents. Journal of Bioscience and Bioengineering . , 119(4), 464-469.

Supplement Facts

Serving Size: 3 Capsules
Servings Per Container: 30
Amount Per Serving % Daily Value**
Calories 13   <2%
Calories from Fat 10  
Total Fat 1 g 2%
Saturated Fat 0.20 g <2%
Monounsaturated Fat 0.20 g
Polyunsaturated Fat 0.60 g
Total Carbohydrates 0.50 g <2%
Other Carbohydrates 0.50 g
Omega 3 fish oil
[Providing 36% EPA (Eicosapentaenoic acid) (360 mg) and 24% DHA (docosahexaenoic acid) (240 mg)]
1000 mg
D-Limonene 250 mg
Rosemary extract

(Rosmarinus officinalis) (leaves) [Standardized for 6% carnosic acid (6 mg), 1% rosmarinic acid (1 mg), 1.5% ursolic acid (1.5 mg)]

100 mg
Meriva® Turmeric Phytosome™

(Curcuma longa rhizome/Glycine max soybeans) [Standardized to 18-22% curcuminoids (18-22 mg)]

100 mg
Ashwagandha extract

(Withania somnifera) (roots) [Standardized for 1.0% total alkaloids (0.5 mg), 1.5% total withanolides (0.75 mg), and 0.25% total withaferin-A (0.125 mg)]

50 mg
Barberry extract

(Berberis vulgaris) (root bark) [Standardized for 6% Alkaloids as Berberine (1.5 mg)]

25 mg
Black Cumin Oil

(Nigella Sativa) (seed)

25 mg
Boswellin

Boswellia serrata (resin) extract [Standardized for 65% total organic acids (32.5 mg), 35% b-boswellic acids (17.5 mg)]

50 mg
Bromelain
(from pineapple) (2400 gelatin digestive units per gram)
25 mg
Capsimax®

Capsicum Extract (Capsicum annum L) (fruit) [Standardized to minimum 2% Capsaicinoids (0.5 mg)]

25 mg

Coptis chinensis extract (root) [Standardized for 5% Berberine (1.25 mg)]

25 mg
Ginger root extract

(Zingiber officinale) [Standardized for 5% gingerols (5 mg)]

100 mg
Holy basil extract

(Ocimum sanctum) (leaf) [Standardized for minimum 2.5% Ursolic and Oleanolic Acids (2.5 mg)]

100 mg
Green tea extract

(Camellia sinensis) (dried leaves) [Standardized for 95% Polyphenols (95 mg), 45% Epigallocatechin-3-P-gallate (45 mg)]

100 mg
Polygonum cuspidatum extract (root)

[Standardized to 50% trans-Resveratrol (12.5 mg)]

25 mg
Oregano 4:1 extract

(Origanum vulgare) (herb)

25 mg
Skullcap herb powder

(Scutellaria lateriflora L.)

25 mg
† Daily Value not established.
** Daily Values are based on a 2,000 calorie per day diet.


Suggested Use

Take 3 capsules daily, preferably with a meal, as a dietary supplement or as directed by a qualified health care professional.

Warnings

If you are pregnant, nursing, or taking any medications, consult your doctor before use. Discontinue use and consult doctor if any adverse reactions occur.

 
Enflamen™ Label