Patient One Enflamen™ mediates activity of proinflammatory prostaglandins and enzymes with a broad range of standardized botanical extracts, antioxidants and omega-3 fish oil. Enflamen’s comprehensive nutritional support modulates inflammation throughout the body while promoting targeted, soothing comfort in the joints and connective tissue. Additionally, Enflamen supports effective functioning of macrophage immune cells and enhances the body’s natural defense system.
Omega-3 Fish Oils:
Omega-3 polyunsaturated fatty acids (PUFA) from fish oil possess potent immunomodulatory activities. The eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in Enflamen influence production of beneficial eicosanoids that modulate inflammatory responses but are also believed to act upon gene expression and intracellular signaling pathways to promote normal immune responses.
Meriva® Turmeric Phytosome™
Turmeric’s active constituent curcumin acts as an orchestrator of whole body inflammatory responses, influencing pro-inflammatory COX enzymes, their transcription factors and gene expression. However, turmeric’s absorption is poor. Meriva, a patented Phytosome delivery form of curcumin, binds turmeric’s curcuminoids to phosphatidylcholine to enhance oral absorption and bioavailability by up to 29X. The improved oral bioavailability of curcumin as Meriva® has been translated into clinical efficacy for addressing the natural inflammatory response function at dosages significantly lower than those associated to uncomplexed curcumin.
This patented extract of Boswellia serrata, a resin mainstay of Traditional Chinese and Ayurvedic wellness traditions, has been found to stabilize mast cells, inhibit synthesis and modify release of proinflammatory mediators. Boswellia serrata also appears to work as a non-redox inhibitor of 5-lipoxygenase enzymes.
A key component of rosemary, rosmarinic acid, increases the production of anti-inflammatory signaling molecules while reducing the production of pro-inflammatory leukotrienes. It also inhibits a key step of the complement system, an alternate pathway of inflammation. In addition, the antioxidant properties of rosemary extract can help reduce cellular damage caused by free radicals that are released during the inflammatory process.
Used since antiquity, Zingiber officinale has demonstrated therapeutic benefits for joint and muscle discomfort. The anti-inflammatory effect of ginger has been scientifically proven by its potential inhibitory effect in reducing prostaglandin synthesis and leukotriene biosynthesis.
An important medicinal plant used in traditional Indian medicine, Withania somnifera’s anti-inflammatory effect is believed to be due to its alkaloid and withanolide contents.
European barberry root appears to have anti-inflammatory activity, believed to be mediated by its alkaloid constituent, berberine. Preliminary research suggests that berberine blocks production of the pro-inflammatory cytokines interleukin-1 (IL1)-beta and tumor necrosis factor (TNF)-alpha by blocking nuclear factor-kappaB, the transcription factor responsible for regulation of cytokine production.
Black cumin oil:
Low concentrations of the constituent nigellone have been shown to inhibit the release of histamine from mast cells in animals. Black [cumin] seed is thought to have immune-protectant effects. Preliminary evidence suggests it may enhance the production of certain human interleukins and alter macrophages.
Bromelain’s anti-inflammatory action is in part a result of inhibiting the generation of bradykinin at the inflammatory site via depletion of the plasma kallikrein system, as well as limiting the formation of fibrin by reduction of clotting cascade intermediates. Research suggests that bromelain reduces leukocyte migration into inflamed areas and prevents firm adhesion of leukocytes to blood vessels at the site of inflammation.
Holy basil extract:
Holy basil (Ocimum sanctum) leaf extract seems to have both central and peripheral analgesic activity. Constituents of the leaves and stems of holy basil appear to inhibit the cyclooxygenase (COX) pathway of arachidonic acid metabolism.
Polygonum cuspidatum extract:
An active component from the roots of Polygonum cuspidatum has been reported to exhibit anti-inflammatory properties. Research indicates that emodin is a potent inhibitor of NF-kappa B activation and expression of adhesion molecules and thus could be useful in treating various inflammatory conditions.
Scullcap herb powder:
Scullcap has been used to treat inflammatory-related disorders in China and Japan for centuries. The plant root has a particularly high flavonoid content (over 35 %) giving it a yellow color, hence its traditional name of golden root. These flavonoids selectively inhibit enzymes in the arachidonic acid cascade as well as possess antioxidant, antiviral, antiretroviral, antibacterial, and sedative properties.
Capsimax is a proprietary matrix that supplies chili pepper-sourced capsaicinoids without gastrointestinal side effects. Capsimax’s capsaicinoids promote soothing whole-body comfort that complements Enflamen’s inflammation-modulating activity.