Enflamen™
  • Gluten Free
  • Non-GMO
  • Vegetable Caps

Enflamen™

Comprehensive blend of standardized botanical extracts, antioxidants and Omega-3 fatty acids to support healthy inflammatory response in the body*

  • Promotes soothing comfort in joints and connective tissues*
  • Optimizes flexibility, range of motion and mobility*
  • Supports healthy cytokine balance*
  • Protects against oxidative stress*

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Patient One Enflamen™ mediates activity of pro-inflammatory prostaglandins and enzymes with a broad range of standardized botanical extracts, antioxidants and omega-3 fish oil. Enflamen’s comprehensive nutritional support promotes a healthy inflammatory response throughout the body while promoting soothing comfort in the joints and connective tissue. Additionally, Enflamen supports effective functioning of macrophage immune cells and enhances the body’s natural defense system.

Key Ingredients

 
Omega-3 Fish Oil: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) influence production of beneficial eicosanoids that support a healthy inflammatory response and are also believed to act upon gene expression and intracellular signaling pathways to promote normal immune responses. Fish oil also promotes optimal joint function and supports healthy connective tissue.

Meriva® Turmeric Phytosome™: It's active constituent curcumin acts as an orchestrator of whole body inflammatory response, influencing pro-inflammatory enzymes, their transcription factors and gene expression. However, turmeric’s absorption is poor. Meriva, a patented phytosome delivery form of curcumin, binds turmeric’s curcuminoids to phosphatidylcholine to enhance oral absorption and bioavailability by up to 29X. The improved oral bioavailability of curcumin as Meriva® has been translated into clinical efficacy at dosages significantly lower than those associated with uncomplexed curcumin.
 
Boswellin™, a patented extract of Boswellia serrata, is a mainstay of Chinese and Ayurvedic wellness traditions found to stabilize mast cells, inhibit synthesis and modify release of proinflammatory mediators. Boswellia serrata also appears to work as a non-redox inhibitor of 5-lipoxygenase enzymes.

Rosemary Extract’s key component, rosmarinic acid, influences the production of certain molecules known to support a healthy inflammatory response. The antioxidant properties of rosemary can help support cellular damage caused by free radicals that are released during the inflammatory process.

Ashwagandha (Withania Somnifera), an important plant used in traditional Indian practices, supports a healthy inflammatory response believed to be due to its alkaloid and withanolide contents.

Barberry Root appears to modulate inflammation via its alkaloid constituent, berberine. Preliminary research suggests that berberine blocks production of the pro-inflammatory cytokines interleukin-1 (IL1)-beta and tumor necrosis factor (TNF)-alpha by
blocking nuclear factor-kappaB, the transcription factor responsible for regulation of cytokine production.

Black Cumin Oil: Low concentrations of the constituent nigellone have been shown to inhibit the release of histamine from mast cells in animals. Black cumin seed is thought to have  immune-supportive effects. Evidence suggests it may enhance the production of certain human interleukins and alter macrophages.

Bromelain promotes a healthy inflammatory response in part by inhibiting the generation of bradykinin at the inflammatory site via depletion of the plasma kallikrein system, as well as limiting the formation of fibrin by reduction of clotting cascade intermediates. Research suggests that bromelain reduces leukocyte migration into inflamed areas.

Holy basil extract (Ocimum sanctum) seems to have both central and peripheral soothing activity. Constituents of the leaves and stems of holy basil appear to inhibit the pathway of arachidonic acid metabolism.

Polygonum cuspidatum extract: An active component from the roots of Polygonum cuspidatum has been shown to support a healthy inflammatory response. Research indicates that emodin is a potent inhibitor of NF-kappa B activation and expression of adhesion molecules.

Scullcap herb root has a particularly high flavonoid content (over 35%) giving it a yellow color, hence its traditional name of golden root. These flavonoids selectively inhibit enzymes in the arachidonic acid cascade as well as possess antioxidant properties. 

Capsimax® is a proprietary matrix that supplies chili pepper-sourced capsaicinoids without gastrointestinal side effects. Capsaicinoids bind to the nerve receptor TRPV1 to promote soothing whole-body comfort. 

 

References

  1. Bowden RG, et al. Nutr Clin Pract. 2009; 24(4):508-12.
  2. Belcaro G., et al., Panminerva Medica. 2010; 52(2 Suppl 1):55-62.
  3. Ammon, H. et al. J Ethnopharmacol. 1993; 38(2-3):113-119
  4. Kimmatkar, N., et al. Phytomedicine. 2003; 10(1):3-7.
  5. Altinier, G., et al. L. Journal of Agriculture & Food Chemistry. 2007; 1718-1723.
  6. Badreldin, A., et al. Food and Chemical Toxicology. 2008; 46:409-420.
  7. Chandrasekhar, K, et al. Indian Journal of Medicine. 2012; 34(3):255-262.
  8. Choudhury, S, et al. Journal of Ethnopharmacology. 2014; 154:148-155.
  9. Lee, C, et al. Journal of Bioscience and Bioengineering. 2015; 119(4):464-469.
  10. Cleland, L, et al. Arthritis Research & Therapy. 2006; 8:202

Supplement Facts

Serving Size: 3 Capsules
Servings Per Container: 30
Amount Per Serving % Daily Value**
Calories 13   <2%
Total Fat 1 g <2%
Saturated Fat 0.20 g <2%
Monounsaturated Fat 0.20 g
Polyunsaturated Fat 0.60 g
Total Carbohydrates 0.50 g <2%
Other Carbohydrates 0.50 g
Omega 3 fish oil
[Providing 36% EPA (Eicosapentaenoic acid) (360 mg) and 24% DHA (docosahexaenoic acid) (240 mg)]
1000 mg
D-Limonene 250 mg
Rosemary extract

(Rosmarinus officinalis) (leaves) [Standardized for 6% carnosic acid (6 mg), 1% rosmarinic acid (1 mg), 1.5% ursolic acid (1.5 mg)]

100 mg
Meriva® Phytosome Turmeric Complex

(Curcuma longa rhizome/Glycine max soybeans) [Standardized to 18-22% curcuminoids (18-22 mg)]

100 mg
Ashwagandha extract

(Withania somnifera) (roots) [Standardized for 1.0% total alkaloids (0.5 mg), 1.5% total withanolides (0.75 mg), and 0.25% total withaferin-A (0.125 mg)]

50 mg
Barberry extract

(Berberis ssp) (bark/root bark) [Standardized for 6% Berberine (1.5 mg)]

25 mg
Black Cumin Oil

(Nigella Sativa) (seed)

25 mg
Boswellin®

Boswellia serrata (resin) extract [Standardized for 70% total organic acids (35 mg), 20% b-boswellic acids (10 mg)]

50 mg
Bromelain
(from pineapple) (2400 gelatin digestive units per gram)
25 mg
Capsimax®

Capsicum Extract (Capsicum annum L) (fruit) [Standardized to minimum 2% Capsaicinoids (0.5 mg)]

25 mg

Coptis chinensis extract (root) [Standardized for 5% Berberine (1.25 mg)]

25 mg
Ginger root extract

(Zingiber officinale) [Standardized for 5% gingerols (5 mg)]

100 mg
Holy basil extract

(Ocimum sanctum) (leaf) [Standardized for minimum 2.5% Ursolic Acid (2.5 mg)]

100 mg
Green tea extract

(Camellia sinensis) (dried leaves) [Standardized for 95% Polyphenols (95 mg), 45% Epigallocatechin-3-P-gallate (45 mg)]

100 mg
Polygonum cuspidatum extract (root)

[Standardized to 50% trans-Resveratrol (12.5 mg)]

25 mg
Oregano 4:1 extract

(Origanum vulgare) (herb)

25 mg
Scullcap herb powder

(Scutellaria lateriflora L.)

25 mg
† Daily Value not established.
** Daily Values are based on a 2,000 calorie per day diet.


Suggested Use

Take 3 capsules daily as a dietary supplement, or as directed by your health practitioner. Store in a cool, dry place.

Warnings

If you are pregnant, nursing, or taking any medications, consult your health practitioner before use. Discontinue use and consult your health practitioner if any adverse reactions occur. Keep out of reach of children. Use only if safety seal is intact.

 
Enflamen™ Label