Pycnogenol® OPC Complex 300 mg (30 caps)

Pycnogenol® OPC Complex 300 mg (30 caps)
  • Gluten Free
  • Non-GMO
  • Vegetarian
  • Vegetable Caps

Nutritional support for peak vitality across multiple body systems and free radical defense for overall healthy aging

  • Reduces oxidative damage to vital tissues
  • Supports endothelial function
  • Increases nitric oxide production
  • Promotes healthy inflammatory response
  • Supports joint mobility and flexibility

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Product Information Sheet (PDF)

Unique Properties 

Patient One Pycnogenol® OPC Complex 300 mg is a potent super antioxidant formula comprised of multiple OPC’s (Oligomeric Proanthocyanidins)— powerful bioflavonoids that act as free radical scavengers in the human body and promote antioxidant activity and overall healthy aging. This highly absorbable formula features a complex of clinically proven antioxidant compounds with a diverse spectrum of demonstrated health and wellness support functions: promoting heart health, normalizing blood vessel diameter, protecting retinal capillaries, promoting clear respiration, encouraging healthy inflammatory response, supporting youthful and healthy skin, and more.


Key Ingredients

Pycnogenol® Pine Bark:

Pycnogenol, French maritime pine bark, is one of the most evidence-based natural ingredients in the world, with over 220 scientific publications on its safety and efficacy across a variety of areas of health. Often referred to as an OPC and considered a “super antioxidant,” Pycnogenol binds to collagen and elastin, influencing endothelial nitric oxide production, which may promote healthy circulation as well as a vasodilation effect that may also support healthy blood pressure. Pycnogenol is believed to help regulate the immune system and modulate the body’s inflammatory response while increasing skin elasticity and protecting against UV damage.  

Mirtoselect® Bilberry Extract:

Another extensively studied OPC, Mirtoselect standardized bilberry extract, provides 36% anthocyanins—antioxidants that act as potent scavengers of free radicals that have demonstrated a broad range of health benefits. Mirtoselect has been found to be an effective adjunctive therapy for retinal sensitivity and visual acuity, venous health, blood sugar stabilization and healthy inflammatory response. 

Bilberry supports light to dark adjustment through its relationship with the pigment system that mediates both light and dark vision as well as visual adaptation to dimly lit spaces. In the vascular system, bilberry supports the integrity of vascular walls by increasing vitamin C levels within cells, lessening the permeabilizing effect of certain enxymes, stabilizing cell membranes and stimulating the synthesis of collagen and connective tissue. 

Grapeseed Extract:

A unique extract standardized to 95% total proanthocyanidins, grapeseed supplies beneficial compounds and antioxidants from California-grown red and white wine grape seeds. By including lower molecular weight OPCs, bioavailability and absorption is improved—optimizing grapeseed’s ability to stabilize blood vessels, promote circulation and influence blood pressure pathways.

Red Wine Extract:

Red wine extract, standardized to 25% polyphenols, supplies additional high-potency antioxidants. Current evidence strongly supports the protective contribution of polyphenols in cardiovascular and bone health and suggests their defensive role in nervous system health and blood glucose support.  

Citrus Bioflavonoid Complex:

Citrus bioflavonoids appear to have strong antioxidant activity, which has been demonstrated in numerous in vitro and animal studies. Derived from fruits high in vitamin C, citrus bioflavonoids appear to act synergistically with the vitamin to neutralize free radicals. Antioxidant properties of bioflavonoids are thought to be particularly beneficial for capillary strength. 


  • One study investigating Pycnogenol’s influence on CVI (Chronic Venous Insufficiency) found an unexpected benefit: healthy cholesterol support. In the study, 40 patients took 600mg of horse chestnut seed extract or 360mg of Pycnogenol every day over four weeks. At study’s end, researchers found that Pycnogenol not only eased CVI symptoms but was also associated with significantly reduced blood levels of total cholesterol and LDL cholesterol. Pycnogenol’s activity is also believed to inhibit the oxidation that makes LDL cholesterol even worse for heart health.
  • Research suggests that Pycnogenol might be an ideal antioxidant because it is highly absorbable. In one small study, researchers reported that while subjects took 150mg of Pycnogenol daily, their antioxidant capacity (ORAC activity) was increased by 40%. Researchers concluded that Pycnogenol “considerably improves antioxidant protection in plasma”.


  1. Devaraj, S., Vega-Lopez, S., Kaul, N., Schonlau, F., Rohdewald, P., and Jialal, I. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 2002;37(10):931-934
  2. Fitzpatrick DF, Bing B., Rohdewald P. Endothelium-dependent vascular effectsof Pycnogenol. J Cardiovasc.Pharmacol 1998;32(4):509-515
  3. F. M. Campbell, P. F. Nicol, K-M. Moar, M. Cruickshank and N. Hoggard, Lower levels of damaged protein biomarkers in the plasma of overweight type 2 diabetic men following supplementation with a standardised bilberry extract. Proceedings of the Nutrition Society 2012, (71) (OCE2), E130
  4. Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, Högger P Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol® ). J Inflamm 3: 1-6, 2006
  5. Hosseini S, Lee J, Sepulveda RT, Rohdewald P, Watson RR A randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of Pycnogenol® in modifying blood pressure in mildly hypertensive patients. Nutr Res 21: 1251-1260, 2001
  6. Kajimoto S. Recovery effect of VMA intake on visual acuity of pseudomyopia in primary school students. J. New Rem. Clin. 2000, 49, 72-79.
  7. Koch R. Comparative study of Venostasin® and Pycnogenol® in chronic venous insufficiency. Phytother Res 16: 1-5, 2002
  8. Mian E. Antocianosidi e parete dei microvasi nuovi aspetti sul modo d’azione dell’effetto protettivo nelle sindromi da abnorme fragilità capillare. Minerva Med. 1977, 68 (52), 3565-3581
  9. Moini H, Guo Q, Packer L. Protein binding of procyanidins: studies using poly acrylamide gel electrophoresis and French maritime pine bark extract. Methods Enzymol. 2001;335:333-7
  10. Nishioka K, et al. Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans. Hypertens Res 30 (2007: 775-780)
  11. Park YC, Rimbach G, Saliou C, Valacchi G, Packer L. Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-alpha secretion, and NF-kappaB-dependent gene expression in RAW 264.7 macrophages. FEBS Lette. 2000 Jan 14; 465 (2-3): 93-7
  12. Rohdewald P, Reducing the risk for stroke and heart infarction with Pycnogenol®. Eur Bull Drug Res 7:14-18, 1999
  13. Sandhagen B., Red cell fluidity in hypertension. Clin Hemorheol Microcirc. 1999; 21 (3-4): 179-81
  14. Schafer, A., Chovanova, Z., Nuchova, J., Sumegova, K., Liptakova, A., Durackova, Z., and Hogger, P. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomed. Pharmacother. 2006:60 (1): 5-9
  15. Sivonova M, et al. The Effect of Pycnogenol on the Erythrocyte Membrane Fluidity. Gen. Physiol. Biophys. (2004), 23, 39-5
  16. Watson RR, Pycnogenol® and Cardiovascular health. Evid Based Integrative Med 1:27-32, 2003.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 30
Amount Per Serving % Daily Value**
Pycnogenol® (French Maritime Pine Bark Extract) 100 mg
Grapeseed extract

(Vitis vinifera) (inner core of fruit) 

[Standardized for 95% proanthocyanidins (47.5mg)]

50 mg
Red wine extract

(Vitis vinifera) (skin) 

[Standardized for 25% polyphenols (12.5mg)]

50 mg
Mirtoselect® Bilberry fruit

(Vaccinium myrtillus L.) [Standardized ethanolic extract 36% of anthocyanins (18mg)]

50 mg
Citrus bioflavonoid complex

Standardized to 50% bioflavonoids

(25mg) [Proprietary blend of  Flavanone (Hesperidin) and  Flavonones (Naringin, Naringenin 7-B-Rutinoside and others)]

50 mg
† Daily Value not established.

Suggested Use

Take 1 vegetarian capsule daily as a dietary supplement, between meals, or as directed by your health practitioner. Store in a cool, dry place.


If you are pregnant, nursing, or taking any medications, consult your health practitioner before use. Discontinue use and consult health practitioner if any adverse reactions occur. Keep out of reach of children. Use only if safety seal is intact.

Pycnogenol® OPC Complex 300 mg (30 caps) Label