Homocysteine Cardioplex

 Unique Properties

Patient One Homocysteine Cardioplex supplies evidence-backed, broad-spectrum nutritional support for maintaining homocysteine levels already within normal range. Plasma homocysteine can be a serious cardiovascular, endothelial and renal risk factor. Certain B vitamins promote healthy homocysteine; however, B vitamin absorption can decline significantly with age and some patients do not respond to B-6 supplementation. Further, some patients may have genetic enzyme deficiencies that may impair homocysteine metabolism. Homocysteine Cardioplex overcomes these challenges by supplying highly absorbable and bioavailable forms of key B vitamins along with diverse methyl donor nutrients. As it opens multiple pathways for catalyzing homocysteine remethylation to methionine, Homocysteine Cardioplex balances plasma homocysteine levels and promotes overall cardiovascular wellness.  

Key Ingredients

Quatrefolic^®: 

A reduced and active form of folate (vitamin B-9), Quatrefolic, the advanced 5-methyltetrahydrofolate (5 MTHF) form, is bound with natural glucosamine salt to promote easy and complete absorption. Considered the “Fourth Generation” folate, Quatrefolic is significantly more stable and bioavailable than 5 MTHF that is bound to calcium salt. Because Quatrefolic is active when it enters the body, it is better able to influence pathways for homocysteine metabolism. Quatrefolic’s pre-converted status may be especially beneficial for patients with a genetic defect of the folate-converting enzyme methylentetrahydrofolate reductase. 

 

Vitamins B-6 and B-12:

Supplying vitamins B-6 (as pyridoxal-5-phosphate) and B-12 (as methylcobalamin), Homocysteine Cardioplex provides two extensively researched clinical standards for nutritional homocysteine management. B-6 modulates homocysteine’s conversion into cystathione, a key step in its excretion. B-12 is an important donor for enabling homocysteine to be remethylated into methionine. B-12 also works in concert with the coenzyme methionine synthase, creating a primary pathway of remethylation of homocysteine.

 

N-Acetyl L-Cysteine (NAC):

N-Acetyl L-Cysteine (NAC) is a free-form amino acid and precursor to glutathione, the body’s most powerful antioxidant. It is believed to hinder formation of homocysteine at plasma protein binding sites while encouraging efficient elimination of homocysteine via urinary excretion. As it works to promote healthy endothelial function, NAC offers further support for overall cardiovascular wellness.

 

Trimethylglycine (as betaine anhydrous):

Trimethylglycine, also known as betaine, is considered a key player in homocysteine metabolism and has long been administered as a methyl donor for remethylating homocysteine back into methionine. Trimethylglycine (TMG) betaine is a necessary cofactor in the secondary pathway of homocysteine metabolism. Betaine is typically administered to patients who are not responsive to pyridoxine (B-6) and other B vitamins.

 

Magnesium as TRAACS^®:

An acronym for The Real Amino Acid Chelate System, TRAACS is a patented range of proprietary mineral amino acid chelates. TRAACS magnesium (Magnesium Glycinate Chelate Buffered Powder) is an organic mineral form known for its safety and ease of absorption. Featuring a biological advantage in assimilation, TRAACS requires no conversion: It is an active cofactor for promoting efficient homocysteine-to-methionine conversion. Early research also suggests magnesium may support arterial health and play a role in modulating production of the destructive MMP-2 enzyme, which has been linked with homocysteine issues and collagen degradation.

 

 

 

Research

• A meta-analysis of 12 randomized trials that included 1,114 study subjects found that dietary folic acid appeared to reduce blood homocysteine levels by 25%, while vitamin B-12 was associated with another 7% reduction. Researchers concluded that daily supplementation with 0.5-5 mg folic acid and .5 mg vitamin B-12 might be able to reduce blood homocysteine concentrations by 25%-33%.
• In one placebo-controlled study, subjects took betaine, folic acid with placebo, or just a placebo every day for six weeks and were then evaluated for their homocysteine levels. At the study’s end, researchers concluded that betaine reduced fasting plasma homocysteine concentration by ~11%, leading researchers to suggest betaine appears to be highly effective in blocking a rise in plasma homocysteine levels after methionine intake.
• In another study, 60 patients with renal problems undergoing dialysis were given NAC 600 mg, folic acid 5 mg or placebo every day, intravenously, for eight weeks. At study’s end, researchers reported that NAC was associated with significant improvements; homocysteine levels dropped 88.3% in the NAC group versus 23.7% in the placebo group.

References

1. Homocysteine Lowering Trialists’ Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials. Br Med J. 1998;316:894–898.
2. Guo H, et al. Effects of folic acid and magnesium on the production of homocysteine-induced extracellular matrix metalloproteinase-2 in cultured rat vascular smooth muscle cells. Circ J. 2006 Jan;70(1):141-6.
3. Yilmaz H, et al. Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease. Acta Cardiol. 2007 Dec;62(6):579-85.
4. Hultberg B, et al. Plasma homocysteine and thiol compound fractions after oral administration of N-acetylcysteine. Scand J Clin Lab Invest. 1994 Oct;54(6):417-22.
5. Ventura P, et al. N -Acetyl-cysteine reduces homocysteine plasma levels after single intravenous administration by increasing thiols urinary excretion. Pharmacol Res. 1999 Oct;40(4):345-50.
6. Wilcken DE, et al. Homocystinuria--the effects of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med. 1983 Aug 25;309(8):448-53.
7. Wilcken DE, et al. B vitamins and homocysteine in cardiovascular disease and aging. Ann N Y Acad Sci. 1998 Nov 20;854:361-70.
8. Alfthan G, et al. The effect of low doses of betaine on plasma homocysteine in healthy volunteers. Br J Nutr. 2004 Oct;92(4):665-9.
9. Venn BJ, Green TJ, Moser R, et al. Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study. Am J Clin Nutr. 2003 Mar;77(3):658-62. [PMID: 12600857]
10. Streenge G, et al. Betaine supplementation lowers plasma homocysteine levels in healthy men and women. J Nutr. 2003 May;133(5):1291-1295.