• Gluten Free
  • Non-GMO
  • Vegetarian
  • Vegetable Caps

Science-backed ingredients that support healthy weight management

  • Promotes lean tissue mass and body fat reduction
  • Supports healthy abdominal circumference and body composition
  • Promotes fat burning and breakdown of stored fat
  • Supports cardiovascular health
  • Promotes healthy insulin metabolism

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Product Information Sheet (PDF)

Unique Properties

Patient One MediLean supplies a synergistic combination of three clinically supported ingredients—Meratrim®, Capsimax™ and chromium picolinate—in  a convenient 1 capsule dose. This multi-functional formula supports lean muscle mass and reduced body fat by promoting lipolysis (fat breakdown) from improved adiponectin levels, thermogenesis (fat burning), and insulin-modulating activity. The natural ingredients in MediLean promote healthy weight management without the use of stimulants.

Key Ingredients


This unique ingredient is a proprietary blend of extracts from Sphaeranthus indicus flower heads and Garcinia mangostana fruit rind.

Meratrim® demonstrated positive weight management outcomes in three randomized, double-blind, placebo-controlled human clinical studies. An 800 mg daily dose of this ingredient resulted in statistically significant reductions in body weight, BMI, waist and hip circumference that exceeded those achieved via diet and exercise alone. The botanical blend’s effect on body weight and body composition parameters occurred as early as 2 weeks and continued to increase during an 8-week trial.


Capsimax is a concentrated extract of capsaicinoids from red chili peppers (Capsicum annuum)—the naturally occurring compounds that cause the sensation of heat when consuming spicy foods. Capsimax targets several key areas of weight management, including appetite control,  breakdown of fat stores, resting energy expenditure (metabolism) and thermogenesis.

Capsaicin stimulates thermogenesis in three ways. By triggering a burning sensation, tissues contract rapidly, leading to the burning of more calories. Capsaicin also stimulates the release of adrenaline in the body. This speeds up the metabolism and pushes the body to burn more calories and fat. Thirdly, its powerful burning sensation also cuts down on appetite, promoting reduced calorie consumption. 

Capsimax is produced with a controlled-release technology that delivers effective levels of capsaicinoids without stomach irritation. This patented ingredient is backed by multiple studies supporting its role in effective weight management. 

Chromium picolinate:

An essential mineral, chromium picolinate provides chromium that is bound to picolinic acid, which facilitates its absorption. In a study, chromium picolinate supplementation helped reduce carbohydrate intake and mood fluctuations. Studies suggest chromium helps maintain already normal glucose levels and insulin sensitivity.    


  1. Anton SD, Morrison CD, Cefalu WT, Martin CK, Coulon S, Geiselman P, Han H, White CL, Williamson DA. Effects of chromium picolinate on food intake and satiety. Diabetes Technol Ther. 2008 Oct;10(5):405-12. doi: 10.1089/dia.2007.0292. PMID: 18715218; PMCID: PMC2753428.
  2. Deshpande J, Jeyakodi S, Juturu V. Tolerability of Capsaicinoids from Capsicum Extract in a Beadlet Form: A Pilot Study. J Toxicol. 2016;2016:6584649. doi: 10.1155/2016/6584649. Epub 2016 Mar 15. PMID: 27066073; PMCID: PMC4811618.
  3. Kudiganti et al. Lipids in Health and Disease (2016) 15:136 DOI 10.1186/s12944-016-0306-4
  4. Mallare JT, Karabell AH, Velasquez-Mieyer P, et al.: Current and future treatment of metabolic syndrome and type 2 diabetes in children and adolescents. Diabetes Spectrum 2005;18:220–228.
  5. Mariwala, Javahar Kohli, et al. “Accumulating Evidence to Support the Safe and Efficacious Use of a Proprietary Blend of Capsaicinoids in Mediating Risk Factors for Obesity.” Food Science & Nutrition, vol. 9, no. 6, 2021, pp. 2823–2835,
  6. Morde A, Rai D, Acharya M, Padigaru M (2021) Capsaicinoids Increase Resting Metabolic Rate in Healthy Individuals under Fasting Condition. J Obes Overweig 7(2): 201
  7. Schnee DM, Zaiken K, McCloskey WW: An update on the pharmacological treatment of obesity. Curr Med Res Opin 2006; 22:1463–1474.
  8. Stern, Judith S., et al. “Efficacy and Tolerability of an Herbal Formulation for Weight Management.” Journal of Medicinal Food, vol. 16, no. 6, 2013, pp. 529–537,
  9. Stern, J.S., J. Peerson, A.T. Mishra, M.V. Sadasiva Rao, et al. “Efficacy and Tolerability of a Novel Herbal Formulation for Weight Management.” Obesity, vol. 21, no. 5, 2013, pp. 921–927.
  10. Urbina, Stacie L., et al. “Corrigendum to ‘Effects of Twelve Weeks of Capsaicinoid Supplementation on Body Composition, Appetite and Self-Reported Caloric Intake in Overweight Individuals’ Appetite 113 (2017) 264–273.” Appetite, vol. 131, 2018, p. 169.

Supplement Facts

Serving Size: 1 capsule
Servings Per Container: 60
Amount Per Serving % Daily Value**
Chromium (as Chromium picolinate) 100 mcg
Meratrim® Proprietary Blend

(Sphaeranthus indicus [flower heads] extract, Garcinia mangostana [fruit rind] extract) [Standardized to min 3% 7-Hydroxyfrullanolide and min 2% alpha-Mangostin

400 mg
Capsimax™ Capsicum extract (whole chilli pepper)


Standardized to min 2% Total Capsaicinoids (capsaicin, dihydrocapsaicin, nordihydrocapsaicin) [1mg]

50 mg
† Daily Value not established.

Suggested Use

Adults 18 and older take 1 capsule 30 minutes before breakfast and 1 capsule 30 minutes before dinner, or as directed by healthcare practitioner. Store in cool, dry place.


If you are pregnant, nursing, or taking any medications, consult your healthcare practitioner before use. Discontinue use and consult your healthcare practitioner if any adverse reactions occur. Keep out of reach of children. Use only if safety seal is intact.