Patient One bone, joint and muscle support supplements supply evidence-backed nutrients in their most bioavailable forms, precisely calibrated with cofactors for maximum absorption. Our formulas include some of today’s breakthrough branded ingredients that promote soothing joint comfort, cartilage rejuvenation, healthy neuromuscular contraction, and peak bone mineralization.
Patient One Marine Collagen provides hydrolyzed marine collagen for easy absorption, along with synergistic co-factors that support collagen production. This unflavored powder is tasteless and odorless and readily dissolves in liquids or soft foods.
As a major component of skin, collagen plays a role in its elasticity and hydration. Collagen helps make sure that cartilage is strong enough to absorb shock and protect joints from damage, while also enabling bones to move fluidly without friction. Collagen is also a vital component of the gut’s connective tissue and may help support the protective lining of the stomach and intestinal walls.
The body naturally produces collagen, though production slows down as we age, beginning in our mid 20s. Collagen can be damaged over time by hormones, stress, poor nutrition, pollution and sun exposure.
Patient One Marine Collagen supplies a 12 gram serving of Types I, II & III collagen peptides, sustainably sourced from wild caught, deep-sea fish. Our hydrolyzed peptides feature a small particle size and low molecular weight, allowing the collagen to be more readily absorbed and digested by the body when compared to bovine- or porcine-sourced collagen.
The typical amino acid profile for a serving of Patient One Marine Collagen is shown below. Our formula contains high content of the amino acids glycine and proline, as well as supplies hydroxyproline, a major component of collagen. Hydroxyproline and proline play key roles for collagen stability. Functions of proline include helping form collagen, regenerating cartilage, forming connective tissue and maintaining healthy joints, restoring skin damage and wounds, and supporting the gut lining. Glycine is found in high concentrations in the body's skin, connective tissues of the joints and muscle tissue. It is one of the key amino acids used to form collagen and gelatin.
Collagen Building Complex
The body makes collagen by combining amino acids. Because the process also requires vitamin C, zinc and copper, Patient One Marine Collagen includes these important co-factors. These nutrients keep the enzymes required for collagen and elastin production in an activated state and help maintain optimal collagen density and stability.
Copper is essential for the cross-linking of adjacent collagen fibers, resulting in a “mature collagen network.” Cross-linking consequently increases collagen network density and minimizes the appearance of wrinkles and fine lines. It is also suggested that copper supplementation increases both collagen type I and elastin gene expression. This co-factor also supports cell proliferation, promoting repair of damaged skin and wounds.
One of the many health benefits of zinc is promoting the synthesis of collagen and bone mineralization. Zinc contributes to wound healing and healthy skin by stimulating gene expression for collagen synthesis.
Vitamin C is essential for the production of collagen, keeping the enzymes required for this process in their active states. Proline and lysine are hydroxylated through the donation of electrons from Vitamin C, stimulating production of all types of collagen. This process maintains optimal collagenic density and mature collagen networks.
Our formula also provides Hyaluronic Acid (HA) as a supplementary ingredient that contributes to collagen synthesis. By counteracting the effects of IL-1 fibroblasts which inhibit collagen production, HA allows for collagen to be synthesized.
Nearly 50% of all hyaluronic acid in the body is found in the skin. HA is a key molecule involved in skin moisture and collagen and elastin stimulation. Water readily binds to hyaluronic acid, creating a jelly-like dermal space filler between collagen and elastin, which work together to give skin its shape and firmness and help make skin soft and smooth.
As we age, the synovial fluid that provides lubrication and reduces friction between the cartilage and joints during movement begins to break down and may cause joint discomfort. HA is a major component of synovial fluid that enables smooth movement of and provides cushioning for joints.
Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015). The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: Evidence from an ex vivo model and randomized, placebo?controlled clinical trials. Journal of Cosmetic Dermatology, 14(4), 291–301.
Bolke, L., Schlippe, G., Gerß, J., & Voss, W. (2019). A collagen supplement improves skin hydration, elasticity, roughness, and density: Results of a randomized, placebo-controlled, Blind Study. Nutrients, 11(10), 2494.
Boyera, N., Galey, I., & Bernard, B. A. (1998). Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. International Journal of Cosmetic Science, 20(3), 151–158.
Chasapis, C. T., Ntoupa, P.-S. A., Spiliopoulou, C. A., & Stefanidou, M. E. (2020). Recent aspects of the effects of zinc on human health. Archives of Toxicology, 94(5), 1443–1460.
Chung, K. W., Song, S. H., & Kim, M.-seok. (2021). Synergistic effect of copper and amino acid mixtures on the production of extracellular matrix proteins in skin fibroblasts. Molecular Biology Reports, 48(4), 3277–3284.
Grosso, G., Bei, R., Mistretta, A., Marventano, S., Calabrese, G., Masuelli, L., Giganti, M. G., Modesti, A., Galvano, F., & Gonzalez, D. (2013). Effects of vitamin C on health: A review of evidence. Frontiers in Bioscience, 18(3), 1017.
Harris, E. D., Rayton, J. K., Balthrop, J. E., Di Silvestro, R. A., & Garcia-de-Quevedo, M. (2008). Copper and the synthesis of elastin and collagen. Novartis Foundation Symposia, 163–182.
Kim, D.-U., Chung, H.-C., Choi, J., Sakai, Y., & Lee, B.-Y. (2018). Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity, and wrinkling in human skin: A randomized, double-blind, placebo-controlled study. Nutrients, 10(7), 826.
Maia Campos, P. M., Franco, R. S., Kakuda, L., Cadioli, G. F., Costa, G. M., & Bouvret, E. (2021). Oral supplementation with hydrolyzed fish cartilage improves the morphological and structural characteristics of the skin: A double-blind, placebo-controlled clinical study. Molecules, 26(16), 4880.
Nawrat, P., Surazynski, A., Karna, E., & Palka, J. A. (2005). The effect of hyaluronic acid on interleukin-1-induced deregulation of collagen metabolism in cultured human skin fibroblasts. Pharmacological Research, 51(5), 473–477.
Przylipiak, A., Donejko, M., Rysiak, E., Miltyk, W., Galicka, E., Przylipiak, J., Zareba, I., & Surazynski, A. (2015). Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts. Drug Design, Development and Therapy, 6225–6233.
Seo, H.-J., Cho, Y.-E., Kim, T., Shin, H.-I., & Kwun, I.-S. (2010). Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells. Nutrition Research and Practice, 4(5), 356–361.
Telang, P. S. (2013). Vitamin C in dermatology. Indian Dermatology Online Journal, 4(2), 143–146.
Serving Size: 1 scoop
Servings Per Container: 30
Amount Per Serving
% Daily Value**
Vitamin C (as ascorbic acid)
Zinc (as TRAACS® zinc bisglycinate chelate)
Copper (as TRAACS® copper bisglycinate)
Collagen Peptides (Types I & III) (Hydrolyzed Fish Collagen)
Collagen Peptides (Type II) (Cartidyss® Hydrolyzed Fish Cartilage)
Hyaluronic acid (sodium hyaluronate)
† Daily Value not established.
** Daily Values are based on a 2,000 calorie per day diet.
fish (cod, pollock, haddock, skate)
Made with ingredients that are free of: milk, egg, peanuts, crustacean shellfish, soy, tree nuts, wheat, yeast, gluten, sesame and GMOs.
TRAACS® is a registered trademark of Albion Labs, Inc.
Cartidyss® is a registered trademark of Abyss Ingredients, France.
Mix 1 scoop (approx. 13 g) with 6-8 oz. of water or preferred beverage once daily, or as directed by your health practitioner. Store in a cool, dry place.
If you are pregnant, nursing, or taking any medications, consult your health practitioner before use. Discontinue use and consult your health practitioner if any adverse reactions occur. Keep out of reach of children.
Use only if safety seal is intact.